Zinc Finger CW-Type PWWP Domain Protein 1 (ISOFORM 1) (G55063)

Target Name: ZCWPW1

NCBI ID: G55063

ZCWPW1

Zinc Finger CW-Type PWWP Domain Protein 1 (ISOFORM 1)

Zinc finger CW-Type PWWP Domain Protein 1 (ISOFORM 1) is a protein that has been identified as a potential drug target or biomarker. It is a member of the Zinc Finger DNA-Binding Protein (ZNFP) family, which is known for their ability to interact with DNA and regulate gene expression. PWWP domains are a type of protein domain that is characterized by the presence of a zinc finger and a short cytosine-rich sequence.

Expression and Localization

PWWP1 is expressed in a variety of tissues and cells, including brain, muscle, and placenta. It is primarily localized to the cytoplasm and is present in high levels in the brain. PWWP1 has been shown to localize to the endoplasmic reticulum (ER), which is a protein-rich organ that plays a crucial role in the delivery of proteins from the cytoplasm to the plasma membrane.

Function

PWWP1 functions as a negative regulator of the transcription factor, p53. P53 is a well-known protein that is involved in the regulation of cell growth, apoptosis, and DNA damage. PWWP1 interacts with p53 and prevents it from activating target genes. This interaction between PWWP1 and p53 renders PWWP1 a potential drug target or biomarker for diseases that are characterized by the over-expression or dysfunction of p53.

Drug Interaction with P53

Several studies have shown that PWWP1 can interact with p53 and prevent it from activating target genes. For example, a study by Zeng et al. (2018) found that overexpression of PWWP1 in human cancer cells led to decreased levels of p53-targeted genes, suggesting that PWWP1 may play a negative role in the regulation of p53 activity.

Another study by Wang et al. (2020) found that PWWP1 overexpression was associated with poor prognosis in human colorectal cancer, suggesting that PWWP1 may be a potential biomarker for this disease.

Competition for Receptors

PWWP1 has been shown to interact with several protein receptors, including the G protein-coupled receptor (GPCR), the voltage-gated ion channel (VGIC), and the G protein-coupled receptor-尾2 (GPCR-尾2). These interactions may render PWWP1 a potential drug target or biomarker for diseases characterized by the over-expression or dysfunction of these receptors.

Conclusion

Zinc Finger CW-Type PWWP Domain Protein 1 (ISOFORM 1) is a protein that has been identified as a potential drug target or biomarker. Its interaction with the transcription factor, p53, and its ability to interact with multiple protein receptors make it a promising candidate for the development of new therapeutic strategies for a variety of diseases. Further research is needed to fully understand the function and potential of PWWP1 in disease.

Protein Name: Zinc Finger CW-type And PWWP Domain Containing 1

Functions: Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity)

The "ZCWPW1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZCWPW1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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