Understanding INO80E: A Potential Drug Target and Biomarker for Various Diseases

Target Name: INO80E

NCBI ID: G283899

INO80E

Understanding INO80E: A Potential Drug Target and Biomarker for Various Diseases

INO80E, a 80kDa protein, is a key component of the INO80 complex, which plays a crucial role in the regulation of chromatin structure and gene expression. INO80E has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the structure, function, and potential therapeutic applications of INO80E.

Structure and Localization

The INO80 complex is a protein-protein interaction network that consists of eight subunits, including INO80A, INO80B, INO80C, INO80D, INO80E, INO80F, INO80G, and INO80H. The INO80 complex has been shown to play a role in the regulation of chromatin structure and gene expression by modifying the chromatin microenvironment and interacting with various nuclear proteins.

INO80E is a 80kDa protein that consists of 155 amino acid residues. It has a characteristic Rossmann-fold structure that is similar to other proteins that contain a nucleotide-binding oligomerization (NBO) domain. NBO domains are known for their ability to form a covalent complex with nucleotides, which allows them to participate in various cellular processes, including DNA replication, transcription, and DNA-protein interactions.

Function

INO80E is a key component of the INO80 complex, which is responsible for the regulation of chromatin structure and gene expression. The INO80 complex has been shown to play a role in the regulation of microRNA (miRNA) expression by binding to the miRNA-protein interaction site on target genes.

In addition to its role in the INO80 complex, INO80E has also been shown to play a role in the regulation of gene expression in various cellular contexts. For example, INO80E has been shown to interact with the transcription factor, p53, and enhance its transcriptional activity. This interaction between INO80E and p53 suggests that INO80E may be a potential drug target for the prevention or treatment of p53-mediated diseases.

Potential Therapeutic Applications

The potential therapeutic applications of INO80E are vast and varied. INO80E has been shown to be a potential drug target for the treatment of various cancers, including breast, ovarian, and colorectal cancers. INO80E has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

In addition to its potential therapeutic applications, INO80E has also been shown to be a potential biomarker for various diseases. The INO80E gene has been shown to be expressed in various tissues and cells, including brain, spinal cord, and muscle. This suggests that INO80E may be a useful biomarker for the diagnosis and monitoring of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Conclusion

INO80E is a protein that has been shown to play a crucial role in the regulation of chromatin structure and gene expression. Its characteristic Rossmann-fold structure and its ability to form a covalent complex with nucleotides make it a potential drug target and a biomarker for various diseases. Further research is needed to fully understand the functions of INO80E and its potential therapeutic applications.

Protein Name: INO80 Complex Subunit E

Functions: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

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