Target Name: ZNF135
NCBI ID: G7694
Review Report on ZNF135 Target / Biomarker Content of Review Report on ZNF135 Target / Biomarker
ZNF135
Other Name(s): zinc finger protein 135 | Zinc finger protein 135, transcript variant 1 | Zinc finger protein 61 | Zinc finger protein 78-like 1 | pHZ-17 | Zinc finger protein 135 (isoform 1) | zinc finger protein 61 | zinc finger protein 78-like 1 (pT3) | ZNF78L1 | Zinc finger protein 135 | Zinc finger protein 78-like 1 (pT3) | ZNF135 variant 1 | zinc finger protein 135 (clone pHZ-17) | pT3 | ZNF61 | Zinc finger protein 135 (clone pHZ-17) | ZN135_HUMAN

ZNF135: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF135, a ZNF protein, is a 21-kDa protein that is expressed in various tissues and cells. It is known to be involved in various cellular processes such as cell growth, differentiation, and survival. ZNF135 has also been implicated in the development and progression of various diseases, including cancer. Therefore, targeting ZNF135 may provide new insights into the mechanisms underlying these diseases and may lead to the development of new treatments.

The ZNF135 gene is located on chromosome 16 and encodes a protein that contains a zinc finger domain. The zinc finger domain is a common structural feature that is characterized by a nucleotide-binding oligomerization (NBO) domain and a variable region. The NBO domain is responsible for the interaction with various DNA sequences, while the variable region is responsible for the unique structure of each ZFPs.

ZNF135 is a key regulator of cellular processes that are critical for the survival and growth of various cell types. It is involved in the regulation of cell growth, apoptosis, angiogenesis, and inflammation. ZNF135 has been shown to play a role in the regulation of cell cycle progression, where it promotes the G1/S transition and inhibits the G0/G1 transition. This contributes to the maintenance of cell cycle progression and the regulation of cell size.

In addition to its role in cell cycle regulation, ZNF135 has also been shown to be involved in the regulation of cell survival. Studies have shown that ZNF135 can induce the expression of cell survival genes, such as Bcl-2, which is a protein that can prevent cell apoptosis. Bcl-2 has been shown to be a potential drug target for various diseases, including cancer. Therefore, targeting ZNF135 may be a promising approach for the development of new treatments for cancer.

ZNF135 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. The regulation of angiogenesis is critical for the development of new blood vessels, which are essential for the delivery of oxygen and nutrients to the body's tissues. ZNF135 has been shown to play a role in the regulation of angiogenesis by promoting the production of progenitor cells that can give rise to new blood vessels.

In addition to its roles in cell cycle, survival, and angiogenesis, ZNF135 has also been implicated in the development and progression of various diseases, including cancer. Studies have shown that ZNF135 is often overexpressed in various cancer types, including breast, ovarian, and colorectal cancers. Overexpression of ZNF135 has been shown to promote the growth and survival of cancer cells, making it a potential drug target for cancer treatment.

In conclusion, ZNF135 is a protein that has been shown to play a critical role in various cellular processes, including cell growth, apoptosis, angiogenesis, and the regulation of the cell cycle and cancer development. Therefore, targeting ZNF135 may provide new insights into the mechanisms underlying these diseases and may lead to the development of new treatments. Further research is needed to determine the full role of ZNF135 in cellular processes and its potential as a drug target.

Protein Name: Zinc Finger Protein 135

Functions: Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation

The "ZNF135 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF135 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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