Target Name: ZNF142
NCBI ID: G7701
Review Report on ZNF142 Target / Biomarker Content of Review Report on ZNF142 Target / Biomarker
ZNF142
Other Name(s): zinc finger protein 142 (clone pHZ-49) | ZNF142 variant 1 | ZN142_HUMAN | Zinc finger protein 142 (isoform 1) | NEDISHM | KIAA0236 | Zinc finger protein 142 | HA4654 | Zinc finger protein 142, transcript variant 1 | pHZ-49 | zinc finger protein 142

ZNF142: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including gene regulation, DNA replication, and apoptosis. ZNF142, also known as zinc finger protein 142 (clone pHZ-49), is a member of the ZNF1 family and has been identified as a potential drug target and biomarker.

In this article, we will explore the structure and function of ZNF142, its potential as a drug target, and its potential as a biomarker for various diseases.

Structure and Function

ZNF142 is a 21-kDa protein that consists of 252 amino acid residues. It has a characteristic ZNF1 domain, which is composed of a nucleotide-binding oligomerization (NBO) domain and a carboxy-terminal zinc finger domain. The NBO domain is responsible for protein-protein interactions and is involved in the regulation of gene expression. The zinc finger domain is responsible for the protein's unique structure and function.

The ZNF142 protein functions as a negative regulator of the transcription factor PVOR, which is responsible for the regulation of gene expression in various tissues. PVOR is a key regulator of cell proliferation and has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

ZNF142 has been shown to play a role in the regulation of cellular processes, including cell growth, apoptosis, and DNA replication. It has also been shown to interact with various protein partners, including the transcription factor NF-kappa-B.

Potential Drug Target

ZNF142 has been identified as a potential drug target due to its unique structure and function. The ZNF142 protein is highly conserved across various species, which suggests that it is a good candidate for drug targeting.

One of the potential drug targets for ZNF142 is the inhibition of PVOR activity, which would result in the inhibition of gene expression. This could be achieved through inhibitors of the NBO domain or the zinc finger domain.

Another potential drug target for ZNF142 is the modulation of NF-kappa-B activity, which is a transcription factor that plays a role in the regulation of cellular processes, including inflammation and stress. The ZNF142 protein has been shown to interact with the transcription factor NF-kappa-B, and Therefore, modulation of NF-kappa-B activity may be a potential drug target for ZNF142.

Potential Biomarker

ZNF142 has been shown to play a role in the regulation of cellular processes, including cell growth, apoptosis, and DNA replication. This suggests that it may be a potential biomarker for various diseases.

One potential biomarker for ZNF142-related diseases is the measurement of the levels of ZNF142 in tissues or fluids. This can be done using techniques such as Western blotting, immunofluorescence, or qRT-PCR.

Another potential biomarker for ZNF142-related diseases is the assessment of the impact of drugs on ZNF142 expression and activity. This can be done using techniques such as live cell imaging, biochemical assays, or cell-based assays.

Conclusion

ZNF142 is a unique protein that has been identified as a potential drug target and biomarker. Its structure and function suggest that it plays a crucial role in various cellular processes, including gene regulation, DNA replication, and apoptosis. Further research is needed to fully understand the role of ZNF142

Protein Name: Zinc Finger Protein 142

Functions: May be involved in transcriptional regulation

The "ZNF142 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF142 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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