Target Name: ZNF185
NCBI ID: G7739
Review Report on ZNF185 Target / Biomarker Content of Review Report on ZNF185 Target / Biomarker
ZNF185
Other Name(s): zinc finger protein 185 (LIM domain) | LIM domain protein ZNF185 | Zinc finger protein 185 (isoform 1) | zinc finger protein 185 with LIM domain | sciellin like | Zinc finger protein 185 | Zinc finger protein 185 with LIM domain, transcript variant 1 | ZNF185 variant 1 | SCELL | P1-A | ZN185_HUMAN

ZNF185: A Potential Drug Target and Biomarker

Introduction

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF185, a ZNF gene product, is one of the ZFPs that has gained significant interest due to its unique structure and function. This article will discuss ZNF185 as a drug target and biomarker.

Structure and Function

ZNF185 is a 21-kDa protein that contains a LIM domain, a unique feature for ZFPs. The LIM domain is a shortened form of the N-terminal LIM domain that is found in many ZFPs, including ZNF185. The LIM domain is responsible for the protein's stability and functions as a negative regulator of gene expression.

ZNF185 is involved in various cellular processes, including cell growth, differentiation, and inflammation. It has been shown to play a role in the regulation of T cell development and function, as well as in the regulation of inflammation and immune response.

As a drug target, ZNF185 could be targeted by small molecules or antibodies to modulate its activity and have therapeutic effects on various diseases. For example, inhibition of ZNF185 has been shown to suppress the growth and survival of cancer cells, suggesting that it may be an effective target for cancer treatment.

In addition to its potential therapeutic applications, ZNF185 has also been identified as a potential biomarker for various diseases. The expression of ZNF185 has been shown to be downregulated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This suggests that ZNF185 may serve as a reliable biomarker for these diseases and could be used for early disease detection and monitoring.

Expression and regulation

ZNF185 is a highly expressed protein in various tissues, including human tissues and organs. Its expression is regulated by various factors, including post-transcriptional regulation, RNA-binding proteins (RBP) and phosphorylation.

The expression of ZNF185 is affected by multiple post-transcriptional regulatory mechanisms. For example, RNA-binding protein (RBP) is an important post-transcriptional regulatory mechanism that can bind to specific sequences on DNA, thereby affecting gene expression. The RBP binding sites of ZNF185 have been found to be located at its N-terminus and C-terminus, and these regions may be involved in RBP binding and post-transcriptional regulation.

Phosphorylation is also an important factor in ZNF185 expression. Phosphorylation can change the spatial conformation of a protein and affect its function. The phosphorylation sites of ZNF185 have been found to be located at its N-terminus and C-terminus, and these regions may be involved in phosphorylation modifications.

Functional research

ZNF185 plays an important role in biological processes such as cell growth, differentiation and immune response. For example, studies have shown that ZNF185 can inhibit the growth of tumor cells and promote their apoptosis, thus having anti-tumor effects.

ZNF185 can also participate in the activation and differentiation of immune cells. Studies have shown that ZNF185 can promote the activation of T cells and inhibit their apoptosis, thereby playing an important role in the immune response.

In addition, ZNF185 is also involved in biological processes such as cell signaling and cell cycle regulation. Studies have shown that ZNF185 can phosphorylate and modify PDK4, thereby participating in cell cycle regulation.

Application prospects

ZNF185 is a protein with great application prospects. Research shows that ZNF185 can be used as a drug target and biomarker, and has biological activities such as anti-tumor and immune enhancement.

As a drug target, ZNF185 can be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and immune diseases. Since ZNF185 plays an important role in biological processes, studying its regulatory mechanism and mechanism of action can reveal biological principles and provide a basis for the development of new drugs.

As a biomarker, ZNF185 can be used for early diagnosis of diseases and evaluation of treatment effects.

Protein Name: Zinc Finger Protein 185 With LIM Domain

Functions: May be involved in the regulation of cellular proliferation and/or differentiation

The "ZNF185 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF185 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239 | ZNF24 | ZNF248 | ZNF25 | ZNF250 | ZNF251 | ZNF252P | ZNF252P-AS1 | ZNF253 | ZNF254 | ZNF256 | ZNF257 | ZNF26 | ZNF260 | ZNF263 | ZNF264 | ZNF266 | ZNF267 | ZNF268 | ZNF271P | ZNF273 | ZNF274 | ZNF275 | ZNF276 | ZNF277 | ZNF28 | ZNF280A | ZNF280B | ZNF280C | ZNF280D | ZNF281 | ZNF282 | ZNF283 | ZNF284 | ZNF285 | ZNF285CP | ZNF286A | ZNF286B | ZNF287 | ZNF292 | ZNF295-AS1 | ZNF296 | ZNF3 | ZNF30 | ZNF300 | ZNF300P1 | ZNF302 | ZNF304 | ZNF311 | ZNF316 | ZNF317 | ZNF318 | ZNF319 | ZNF32 | ZNF32-AS1 | ZNF32-AS2 | ZNF32-AS3 | ZNF320