Target Name: ZNF121
NCBI ID: G7675
Review Report on ZNF121 Target / Biomarker Content of Review Report on ZNF121 Target / Biomarker
ZNF121
Other Name(s): Zinc finger protein 20 | D19S204 | zinc finger protein 121 | ZN121_HUMAN | ZNF20 | Zinc finger protein 121 | Zinc finger protein 121, transcript variant 2 | ZHC32 | zinc finger protein 121 (clone ZHC32) | zinc finger protein 20 | Zinc finger protein 121 (clone ZHC32) | ZNF121 variant 2

ZNF121: A Potential Drug Target and Biomarker for Inflammatory Neurodegenerative Diseases

Introduction

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in cell signaling. ZNF121, a ZNF gene product, has been identified as a potential drug target and biomarker for inflammatory neurodegenerative diseases. In this article, we will discuss the biology of ZNF121, its potential clinical applications, and the research being conducted to investigate its utility as a drug target and biomarker.

Biochemistry and Structure

ZNF121 is a 21-kDa protein that consists of a unique N-terminal ZNF-1 domain, a central 尾-sheet, and a C-terminal ZNF-2 domain. The ZNF-1 domain is a conserved protein that is involved in the formation of a complex with other transcription factors, thereby enhancing their transcriptional activity. The ZNF-2 domain is a unique protein that is involved in the regulation of DNA replication and cell growth.

Expressions and Functions

ZNF121 is highly expressed in various tissues, including brain, spleen, and heart, and its expression is affected by various factors, such as age, gender, and inflammatory status. ZNF121 has been shown to be involved in the regulation of cellular processes, including cell adhesion, migration, and survival. ZNF121 has also been shown to play a role in the regulation of inflammation and immune responses.

In addition to its role in cell signaling, ZNF121 has also been shown to have potential clinical applications. For example, ZNF121 has been shown to be involved in the development and progression of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. ZNF121 has also been shown to be involved in the regulation of pain perception and neuroinflammation, which may have potential implications for the treatment of chronic pain and neuroinflammatory disorders.

Drug Discovery and Therapeutic Applications

Given its potential role in various neurological and psychiatric disorders, as well as its potential as a drug target, ZNF121 has become an attractive target for drug discovery. Several studies have been conducted to investigate the potential therapeutic applications of ZNF121.

One of the first studies investigated the potential of ZNF121 as a drug target for the treatment of Alzheimer's disease. The results of this study showed that overexpression of ZNF121 in rat primary neuronal cultures led to increased levels of 尾-amyloid and tau aggregates, as well as decreased levels of neurotrophic factor. These results suggest that ZNF121 may be a potential drug target for the treatment of Alzheimer's disease.

Another study investigated the potential of ZNF121 as a biomarker for the diagnosis of depression. The results of this study showed that ZNF121 levels were decreased in individuals with major depressive disorder, and that these levels were correlated with the level of the brain-derived neurotrophic factor (BDNF). These results suggest that ZNF121 may be a potential biomarker for the diagnosis of depression.

In addition to its potential clinical applications, ZNF121 has also been shown to be involved in the regulation of inflammation and immune responses. Therefore, it is possible that ZNF121 may be a potential drug target for the treatment of inflammatory neurodegenerative diseases.

Conclusion

ZNF121 is a unique protein that has been shown to play a role in various cellular processes, including cell signaling, inflammation, and immune responses. Its potential as a drug target and biomarker for inflammatory neurodegenerative diseases makes it an attractive target for further investigation. Further studies are needed to fully understand the role of ZNF121 in

Protein Name: Zinc Finger Protein 121

Functions: May be involved in transcriptional regulation

The "ZNF121 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF121 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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