Target Name: ZNF140
NCBI ID: G7699
Review Report on ZNF140 Target / Biomarker Content of Review Report on ZNF140 Target / Biomarker
ZNF140
Other Name(s): zinc finger protein 140 | Zinc finger protein 140 (isoform 1) | Zinc finger protein 140, transcript variant 1 | pHZ-39 | ZN140_HUMAN | Zinc finger protein 140 | ZNF140 variant 1

ZNF140: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF140, a ZNF gene product, is one of the ZFPs that has garnered significant attention due to its unique function and potential as a drug target or biomarker.

The ZNF gene family is composed of four members: ZNF1, ZNF2, ZNF3, and ZNF140. ZNF1 and ZNF2 are involved in the regulation of cell growth, while ZNF3 and ZNF140 are involved in the development and maintenance of neural stem cells (NSCs) and their progeny, respectively.

ZNF140 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is characterized by a unique N-terminal domain that consists of a conserved zinc finger and a non-conserved N-terminal region. The zinc finger domain is responsible for the protein's unique structure and function.

The zinc finger domain is a well-established structural feature that is characterized by a specific arrangement of amino acids. In ZNF140, the zinc finger domain is composed of three parallel beta-strands that are separated by a single alpha-helix. domain is responsible for the protein's stability and functions as a critical structural unit.

In addition to its unique structure, ZNF140 has several unique functions that make it an attractive drug target or biomarker. One of its most significant functions is its role in the regulation of stem cell proliferation. ZNF140 has been shown to play a critical role in the self-renewal and differentiation of NSCs, which are a vital source of tissues and organs for regenerative medicine.

ZNF140 has also been shown to play a role in the regulation of cell survival and stress resistance. Studies have shown that ZNF140 can enhance the survival of NSCs under various stress conditions, such as exposure to chemotherapy or radiation. Additionally, ZNF140 has been shown to play a role in the regulation of cell cycle progression, which is critical for the development and maintenance of NSCs.

Another function of ZNF140 is its role in the regulation of neural development and plasticity. Studies have shown that ZNF140 is involved in the regulation of neuronal differentiation and plasticity, which is critical for the development and maintenance of neural tissues.

In addition to its unique functions, ZNF140 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, studies have shown that ZNF140 is overexpressed in various cancer types, including breast, ovarian , and colorectal cancer. Additionally, ZNF140 has been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Despite its potential as a drug target or biomarker, ZNF140 has not yet been studied extensively, and much of its function and potential are still unknown. However, the unique structure and functions of ZNF140 make it an intriguing protein that has the potential to be a valuable drug target or biomarker for various diseases.

In conclusion, ZNF140 is a protein that has garnered significant attention due to its unique structure and functions. Its role in the regulation of stem cell proliferation, stress resistance, neural development and plasticity, and neurodegenerative diseases makes it an attractive potential drug target or biomarker . Further studies are needed to fully understand its function and potential as a drug target or biomarker.

Protein Name: Zinc Finger Protein 140

Functions: May be involved in transcriptional regulation as a repressor

The "ZNF140 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF140 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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