Target Name: ZNF138
NCBI ID: G7697
Review Report on ZNF138 Target / Biomarker Content of Review Report on ZNF138 Target / Biomarker
ZNF138
Other Name(s): Zinc finger protein 138 (isoform 1) | Zinc finger protein 138, transcript variant 1 | zinc finger protein 138 | pHZ-32 | Zinc finger protein 138 | PHZ-32 | zinc finger protein 138 (clone pHZ-32) | ZNF138 variant 1 | Zinc finger protein 138 (clone pHZ-32) | ZN138_HUMAN

ZNF138: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including gene regulation, DNA replication, and cell signaling. ZNF138, also known as Zinc finger protein 138 (isoform 1), is a ZFP that is expressed in various tissues and cell types. Its unique structure and function make it an attractive candidate for drug targeting and biomarker development.

The ZNF138 protein is composed of 218 amino acid residues and has a molecular weight of 24 kDa. It has a characteristic ZNF1-like domain at its extracellular domain, which is responsible for its unique structure and function. The ZNF138 protein localizes to the endoplasmic reticulum (ER) and is predominantly expressed in the liver, heart, and pancreas.

ZNF138 functions as a negative regulator of the transcription factor PVBP. PVBP is a key regulator of hematopoietic stem cell (HSC) proliferation and differentiation, and is involved in the development and maintenance of various tissues, including blood cells, tissues, and organs. ZNF138 plays a vital role in regulating PVBP activity by physically interacting with it and modulating its activity.

The ZNF138-PVBP interaction is critical for the regulation of cellular processes, including cell growth, apoptosis, and inflammation. ZNF138 has been shown to play a role in the regulation of cell cycle progression, apoptosis, and DNA replication. For example, studies have shown that ZNF138 can interact with the transcription factor p21 and prevent its degradation, thereby regulating the p21 level and its role in cell cycle progression.

In addition to its role in cell regulation, ZNF138 has also been shown to play a critical role in the development and maintenance of tissues. For example, studies have shown that ZNF138 is involved in the regulation of tissue homeostasis, including the regulation of cell adhesion and the maintenance of tissue structure.

As a potential drug target, ZNF138 has the potential to intervene in various diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. For example, studies have shown that ZNF138 is involved in the regulation of cancer cell proliferation and has the potential to be a therapeutic target for cancer treatment. In addition, ZNF138 has also been shown to be involved in the regulation of cardiovascular disease, including the regulation of blood pressure and cholesterol levels.

In addition to its potential therapeutic applications, ZNF138 also has the potential to serve as a biomarker for various diseases. For example, studies have shown that ZNF138 is involved in the regulation of cellular processes, including cell growth, apoptosis, and inflammation, making it a potential biomarker for various diseases.

In conclusion, ZNF138 is a unique and highly conserved protein that plays a critical role in various cellular processes. Its structure and function make it an attractive candidate for drug targeting and biomarker development. Further research is needed to fully understand the role of ZNF138 in cellular processes and its potential as a drug target and biomarker.

Protein Name: Zinc Finger Protein 138

Functions: May be involved in transcriptional regulation as a repressor

The "ZNF138 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF138 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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