ZNF165: A Potential Drug Target for Neurodegenerative Diseases
ZNF165: A Potential Drug Target for Neurodegenerative Diseases
ZNF165 (CT53), a protein encoded by the Zinc Finger Nucleotide-containing gene (ZNF1), is a key regulator of cellular processes that are crucial for the development, maintenance, and progression of tissues, including neural cells. ZNF165 has been implicated in a wide range of physiological processes, including cell proliferation, differentiation, migration, and survival.
Recent studies have identified ZNF165 as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. ZNF165 has also been shown to be involved in several cellular processes that are associated with aging, such as chromatin remodeling, DNA damage repair, stress response and apoptosis.
ZNF165 is a 21-kDa protein that is composed of a N-terminal ZNF165 protein and a C-terminal C-type transcription factor-1 (CT53) DNA-binding domain. ZNF165 has been shown to play a role in regulating gene expression and cellular processes, including cell adhesion, migration, and survival.
One of the most significant functions of ZNF165 is its ability to regulate the activity of transcription factors, such as DNA-binding domain-containing transcription factors (DBDs) and DNA-protein interactions (DPIs). ZNF165 has been shown to interact with several DBDs , including ZNF2, SV2, and MBP, and these interactions play a role in regulating gene expression and cellular processes.
ZNF165 has also been shown to play a role in regulating DNA damage repair processes. DNA damage repair is a critical mechanism for maintaining cellular homeostasis and preventing the development of genetic mutations that can lead to diseases such as cancer. ZNF165 has been shown to regulate the activity of several DNA damage repair pathways, including the non-homologous end joining (NHEJ) pathway and the homologous recombinase (HR) pathway.
In addition to its role in regulating DNA damage repair processes, ZNF165 has also been shown to play a role in regulating cell apoptosis. Apoptosis is an important way of cell death and plays a key role in the mitosis, differentiation and regeneration of nerve cells. ZNF165 has been shown to regulate the activity of several apoptosis signaling pathways, including the Bcl-2/Ago-1 signaling pathway, T-cell apoptosis signaling pathway and apoptosis-related gene (p53) signaling pathway.
ZNF165 has also been shown to play a role in regulating cellular processes that are associated with aging, such as chromatin remodeling, DNA damage repair and stress response. Chromatin remodeling refers to the structural changes in chromatin that occur during aging. It is closely related to chromatin availability and the stability of gene expression. DNA damage repair and stress response are important mechanisms for maintaining cellular homeostasis, and they play key roles in the aging process.
Recently, the research team discovered the role of ZNF165 in neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease, cause nerve cell death and loss of function. Studies have found that ZNF165 is dysregulated in neurodegenerative diseases and is closely related to the occurrence and development of neurodegenerative diseases.
ZNF165 is a protein that plays an important role in nerve cells. By regulating processes such as DNA damage repair, apoptosis, and cell proliferation, ZNF165 plays an important role in maintaining cellular homeostasis and maintaining tissue health. The research team is exploring ZNF165 as a drug target to treat neurodegenerative diseases, and is conducting in-depth research on the role of ZNF165 in cancer, neurological diseases, and cancer.
Protein Name: Zinc Finger Protein 165
Functions: May be involved in transcriptional regulation
The "ZNF165 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF165 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
ZNF169 | ZNF17 | ZNF174 | ZNF175 | ZNF177 | ZNF18 | ZNF180 | ZNF181 | ZNF182 | ZNF184 | ZNF185 | ZNF189 | ZNF19 | ZNF195 | ZNF197 | ZNF2 | ZNF20 | ZNF200 | ZNF202 | ZNF204P | ZNF205 | ZNF205-AS1 | ZNF207 | ZNF208 | ZNF209P | ZNF211 | ZNF212 | ZNF213 | ZNF213-AS1 | ZNF214 | ZNF215 | ZNF217 | ZNF219 | ZNF22 | ZNF22-AS1 | ZNF221 | ZNF222 | ZNF223 | ZNF224 | ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239 | ZNF24 | ZNF248 | ZNF25 | ZNF250 | ZNF251 | ZNF252P | ZNF252P-AS1 | ZNF253 | ZNF254 | ZNF256 | ZNF257 | ZNF26 | ZNF260 | ZNF263 | ZNF264 | ZNF266 | ZNF267 | ZNF268 | ZNF271P | ZNF273 | ZNF274 | ZNF275 | ZNF276 | ZNF277 | ZNF28 | ZNF280A | ZNF280B | ZNF280C | ZNF280D | ZNF281 | ZNF282 | ZNF283 | ZNF284 | ZNF285 | ZNF285CP | ZNF286A | ZNF286B | ZNF287 | ZNF292 | ZNF295-AS1 | ZNF296 | ZNF3 | ZNF30 | ZNF300 | ZNF300P1 | ZNF302
