Identifying DPH3 as A Potential Drug Target and Biomarker (G285381)

Target Name: DPH3

NCBI ID: G285381

DPH3

Identifying DPH3 as A Potential Drug Target and Biomarker

The protein DPH3 (doublecortin-like peptide 3) is a protein that is expressed in various tissues of the body, including the brain, heart, and pancreas. It is a zinc finger protein that contains a specific domain called the CSL (conserved short back Text) domain. The CSL domain is a type of domain that is characterized by the presence of a specific sequence of amino acids that is repeated multiple times. This repeated sequence is known as a \"doublecortin\" sequence, which is thought to play a role in the regulation of various cellular processes.

DPH3 function

DPH3 is a protein that is involved in a number of different cellular processes. One of its functions is to regulate the growth and differentiation of various cell types. For example, DPH3 has been shown to play a role in the regulation of neural cell growth and the development of neural circuits.

In addition to its role in cell growth and differentiation, DPH3 is also involved in the regulation of cellular signaling pathways. For example, DPH3 has been shown to play a role in the regulation of the DNA damage response, a signaling pathway that is involved in the repair of DNA damage in response to various cellular stressors, including radiation and chemicals.

DPH3 is also involved in the regulation of cellular immigration. For example, DPH3 has been shown to play a role in the regulation of the movement of immune cells into the brain, where it is thought to help to defend against various infections and diseases.

DPH3 as a drug target

The protein DPH3 has been identified as a potential drug target due to its involvement in a number of different cellular processes. Its zinc finger domain and its ability to interact with various signaling pathways make it an attractive target for small molecules.

One of the potential benefits of targeting DPH3 is its ability to interact with a wide range of signaling pathways, making it a potentially versatile drug. For example, DPH3 has been shown to play a role in the regulation of cellular signaling pathways, including those involved in cell growth, differentiation, and stress response. This makes it an attractive target for small molecules that can modulate these signaling pathways.

In addition to its potential utility as a drug, DPH3 is also a good candidate as a biomarker. Its expression is highly upregulated in response to various stressors, including radiation and chemicals, which makes it a potential indicator of cellular stress. This makes DPH3 a potentially useful biomarker for the study of cellular stress and its impact on various diseases.

Conclusion

In conclusion, the protein DPH3 is a zinc finger protein that is involved in a number of different cellular processes. Its ability to interact with various signaling pathways makes it an attractive target for small molecules, and its upregulation in response to stress makes it a potentially useful biomarker for the study of cellular stress and its impact on various diseases. Further research is needed to fully understand the role of DPH3 in cellular processes and its potential as a drug and biomarker.

Protein Name: Diphthamide Biosynthesis 3

Functions: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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