GPT: Key Enzyme in Metabolism of Alcohol and Other Compounds (G2875)

Target Name: GPT

NCBI ID: G2875

Content of Review Report on GPT Target / Biomarker

GPT

GPT: Key Enzyme in Metabolism of Alcohol and Other Compounds

GPT ( Alanine Transaminase) is a protein that is found in the liver and other tissues in the body. It is a key enzyme that is involved in the metabolism of a variety of compounds, including alcohol, drugs, and some medications.

GPT is a transmembrane protein, which means that it spans the cell membrane and is associated with the mitochondria. It is also a cytoplasmic protein, which means that it is located within the cytoplasm of the cell.

GPT is a monomeric protein, which means that it is made up of a single chain of amino acids. It has a molecular weight of approximately 18 kDa and a pre-native cleavage site at its C-terminus.

GPT is regulated by several different factors, including alcohol, drugs, and some medications. When these substances are introduced into the body, they can induce a response from the liver. In response, GPT is activated and begins to catalyze the metabolism of these substances.

One of the key roles of GPT is its role in the metabolism of alcohol. GPT is known to be sensitive to alcohol and has been shown to be involved in the detoxification of alcohol from the body. When alcohol is ingested, it is metabolized by the liver and converted into a toxic compound called acetaldehyde. GPT is then responsible for breaking down this compound and returning it to its normal form.

In addition to its role in the metabolism of alcohol, GPT is also involved in the metabolism of other drugs and medications. For example, GPT has been shown to be involved in the metabolism of many different types of drugs, including opioids, benzodiazepines, and statins.

GPT is also a potential drug target in its own right. Researchers are currently studying the potential uses of GPT as a therapeutic intervention for a variety of different conditions. For example, GPT has been shown to be effective in treating alcohol addiction and may also be useful in treating other types of addiction, such as substance abuse and nicotine addiction.

In addition to its potential therapeutic uses, GPT is also a valuable biomarker for a variety of different conditions. For example, individuals with certain genetic mutations may have increased levels of GPT in their bloodstream, which could be used as a diagnostic marker for these conditions.

Overall, GPT is a complex and important protein that plays a critical role in the metabolism of a variety of different compounds in the body. Its role in the detoxification of alcohol and its potential therapeutic uses make it an attractive target for further research and development.

Protein Name: Glutamic--pyruvic Transaminase

Functions: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)

The "GPT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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