GPX2: A Potential Drug Target and Biomarker (G2877)

Target Name: GPX2

NCBI ID: G2877

GPX2

GPX2: A Potential Drug Target and Biomarker

Glutathione peroxidase 2 (GPX2) is a protein that is expressed in a variety of tissues throughout the body. It is a key enzyme in the antioxidant response, which helps to protect cells from damage caused by free radicals. GPX2 is also involved in the regulation of cell signaling pathways, and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the challenges in studying GPX2 is its complex structure and function. GPX2 is a 17-kDa protein that contains four distinct domains: an N-terminus, a catalytic center, a disulfide bond, and two C-tertius. The N-terminus is responsible for interacting with other proteins, while the catalytic center is the active site where the enzyme carries out its antioxidant functions. The disulfide bond allows the two C-tertius to be linked together, which is necessary for the enzyme to function.

GPX2 is a strong candidate for drug targeting due to its unique structure and the diseases it is associated with. For example, GPX2 has been shown to be overexpressed in a variety of cancer types, including breast, ovarian, and colorectal cancers. It is also overexpressed in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Additionally, GPX2 has been shown to be involved in the regulation of cell signaling pathways, which makes it a potential target for drugs that target signaling pathways in neurodegenerative diseases.

In addition to its potential as a drug target, GPX2 is also a valuable biomarker for a variety of diseases. For example, GPX2 has been shown to be a potential biomarker for cancer, as its expression is often elevated in cancer tissues. Additionally, GPX2 has been shown to be a potential biomarker for neurodegenerative diseases, as its expression is often elevated in neurodegenerative tissues.

GPX2 is also a potential target for drug development in other diseases, including autoimmune disorders. For example, GPX2 has been shown to be involved in the regulation of immune cell function, which makes it a potential target for drugs that target autoimmune disorders.

In conclusion, GPX2 is a protein that is expressed in a variety of tissues throughout the body and is involved in the antioxidant response, as well as cell signaling pathways. It is a strong candidate for drug targeting due to its unique structure and the diseases it is associated with, and also has potential as a biomarker for a variety of diseases. Further research is needed to fully understand the function and potential of GPX2 as a drug target and biomarker.

Protein Name: Glutathione Peroxidase 2

Functions: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides (PubMed:8428933). Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors (PubMed:8428933)

The "GPX2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPX2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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