GPRK2L: A GPCR Kinase and Potential Drug Target (G2868)

Target Name: GRK4

NCBI ID: G2868

GRK4

GPRK2L: A GPCR Kinase and Potential Drug Target

GPRK2L, or G protein-coupled receptor kinase 2L, is a protein that is expressed in many different tissues and cells in the body. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play an important role in cellular signaling. GPRK2L is one of the kinases that is encoded by the GRK4 gene, which is located on chromosome 7.

The GRK4 gene is one of several genes that encode for proteins that are involved in the intracellular signaling pathway known as the TGF-β pathway. This pathway is a well-established regulator of cell growth, differentiation, and survival, and is involved in many important physiological processes in the body. The TGF-β pathway is activated by the binding of a protein called TGF-β1, which is a cytoplasmic protein that can interact with the GRK4 protein.

The GRK4 protein is a 21-kDa protein that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is involved in the formation of the protein's transmembrane domain, which is responsible for its ability to interact with TGF -尾1. The transmembrane domain is the region of the protein that is involved in the TGF-β pathway, and is composed of a catalytic center and several transmembrane helices. The intracellular domain is the region of the protein that interacts with the TGF-β1 protein and is involved in the regulation of cellular processes such as cell growth, differentiation, and survival.

GPRK2L is a potent inhibitor of TGF-β1 activity, and has been shown to have a wide range of physiological effects in various cell types. For example, GPRK2L has been shown to be involved in the regulation of cell growth, differentiation, and survival, and has been shown to play a role in the development and progression of many diseases, including cancer.

In addition to its role in the TGF-β pathway, GPRK2L is also involved in the regulation of many other cellular processes, including cell signaling, cell adhesion, and neurotransmission. For example, GPRK2L has been shown to be involved in the regulation of neurotransmitter released from neurons, and has been shown to play a role in the development and progression of neurodegenerative diseases.

GPRK2L is also a potential drug target, and has been shown to be involved in the development of several diseases, including cancer. For example, GPRK2L has been shown to be involved in the regulation of the development and progression of breast cancer, and has been shown to play a role in the regulation of the metastasis of colon cancer.

In conclusion, GPRK2L is a protein that is involved in the intracellular signaling pathway known as the TGF-β pathway, and has a wide range of physiological effects in various cell types. It is a potential drug target, and has been shown to be involved in the regulation of many diseases, including cancer. Further research is needed to fully understand the role of GPRK2L in cellular signaling and the development and progression of disease.

Protein Name: G Protein-coupled Receptor Kinase 4

Functions: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2

The "GRK4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GRK4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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