Modulation of NMDA Receptor By GRIN3B: Implications for Neurological Disorders

Target Name: GRIN3B

NCBI ID: G116444

GRIN3B

Modulation of NMDA Receptor By GRIN3B: Implications for Neurological Disorders

Glutamate is a neurotransmitter that plays a crucial role in communication between neurons in the central nervous system (CNS). The N-methyl-D-aspartate (NMDA) receptor subunit 3B (GRIN3B) is a critical protein that modulates the activity of the NMDA receptor. It is expressed in various tissues and cell types in the CNS, including the prefrontal cortical cortex, brainstem, and spinal cord.GRIN3B has been implicated in several neurological disorders, including epilepsy, anxiety, and depression.

TheGRIN3B gene has four exons, which encode the four subunits of the GRIN3B protein (GRIN3B1-4). Each subunit consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is involved in cell adhesion and interaction, the transmembrane domain plays a role in the receptor's internal structure and function, and the intracellular domain is involved in the interaction with other proteins.

GRIN3B1-4 function

GRIN3B is a critical protein that modulates the activity of the NMDA receptor, which is a crucial neurotransmitter involved in pain perception, anxiety, and learning. The NMDA receptor is a G protein-coupled receptor (GPCR), which means it has a significant role in intracellular signaling.

The GRIN3B gene has been shown to play a crucial role in the regulation of pain perception, anxiety, and depression.GRIN3B-/- mice have increased sensitivity to pain and anxiety, suggesting that it may be a potential drug target for these disorders.

GRIN3B has also been shown to play a role in modulating anxiety and depression-like behavior in rats. Studies have shown that GRIN3B-/- mice have increased anxiety-like behavior, and that this can be improved by treating them with the NMDA receptor antagonist, glutamate.

GRIN3B has also been shown to play a role in modulating the expression of genes involved in pain perception and anxiety. For example, studies have shown that GRIN3B-/- mice have decreased levels of the pain gene, TrkA, and increased levels of the anxiety gene, GABA.

GRIN3B interacts with other proteins

GRIN3B is a member of the superfamily of GPCR-伪/尾-纬 subfamilies. It has been shown to interact with several other proteins, including:

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Protein Name: Glutamate Ionotropic Receptor NMDA Type Subunit 3B

Functions: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine

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