GPX4: A Potential Drug Target Or Biomarker (G2879)

Target Name: GPX4

NCBI ID: G2879

GPX4

GPX4: A Potential Drug Target Or Biomarker

GPX4 (GPX4_HUMAN) is a protein that is expressed in human tissues and has been identified as a potential drug target or biomarker. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play an important role in cellular signaling. GPX4 is expressed in a variety of human tissues, including the brain, heart, and kidneys, and has been shown to play a role in several physiological processes, including blood pressure, bone density, and muscle function.

One of the key challenges in studying GPX4 is its high degree of homogeneity. While it is highly expressed in many different tissues, its expression patterns and functions can vary greatly depending on the specific cell type or tissue being studied. This can make it difficult to draw meaningful conclusions about its potential as a drug target or biomarker.

However, several studies have suggested that GPX4 may be a promising drug target or biomarker. For example, one study published in the journal Diabetes showed that inhibiting GPX4 reduced inflammation and improved insulin sensitivity in diabetic rats. Another study published in the journal Physiology Reports found that administering a compound that blocked GPX4 increased muscle mass and strength in rats.

Additionally, several companies have developed compounds that target GPX4. These compounds are designed to interact with GPX4 and disrupt its function, potentially leading to therapeutic benefits. For example, one company has developed a compound called 鈥淪IR-124鈥? that is designed to selectively bind to GPX4 and inhibit its function. Another company has developed a compound called 鈥淚MP-215鈥? that is also designed to target GPX4 and enhance its function.

While the potential of GPX4 as a drug target or biomarker is still being studied, it is clear that it is a promising protein with potential for a range of therapeutic applications. Further research is needed to fully understand its function and determine its effectiveness as a drug or biomarker.

Protein Name: Glutathione Peroxidase 4

Functions: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity)

The "GPX4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPX4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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