Targeting The GRIN2D Subunit for Neurodegenerative Diseases (G2906)

Target Name: GRIN2D

NCBI ID: G2906

GRIN2D

Targeting The GRIN2D Subunit for Neurodegenerative Diseases

Glutamate is a neurotransmitter that plays a crucial role in communication between neurons in the central nervous system (CNS). It is a simple amino acid that can be synthesized in the body and is found in many different types of neural cells. Glutamate is involved in many different functions in the CNS, including learning and memory, mood regulation, and pain perception.

The ionotropic receptor NMDA (N-Methyl-D-Aspartate) is a protein that is found in many different types of neural cells. It is involved in the regulation of many different functions in the CNS, including pain perception, neurotransmitter signaling, and cell survival. The NMDA receptor has four subunits, including the GRIN2D subunit.

The GRIN2D subunit is a protein that is found in the NMDA receptor. It is made up of 224 amino acids and has a molecular weight of 24.1 kDa. The GRIN2D subunit is involved in the regulation of many different functions in the CNS, including pain perception, neurotransmitter signaling, and cell survival.

Drug Targets and Biomarkers

The GRIN2D subunit is a drug target that can be targeted with small molecules. This subunit is also a biomarker that can be used to diagnose neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

One of the potential benefits of targeting the GRIN2D subunit is that it can be used to treat many different types of neurodegenerative diseases. For example, studies have shown that inhibiting the activity of the GRIN2D subunit can protect against neurodegeneration in animal models of Alzheimer's disease and Parkinson's disease. This suggests that targeting this subunit may be a promising new way to treat these diseases.

Another potential benefit of targeting the GRIN2D subunit is that it can be used to diagnose neurodegenerative diseases. The GRIN2D subunit is expressed in many different types of neural cells and is involved in the regulation of many different functions in the CNS. Therefore, detecting the expression of this subunit may be a useful biomarker for diagnosing neurodegenerative diseases.

Pathology and Pharmacology

The GRIN2D subunit is involved in many different functions in the CNS, including pain perception, neurotransmitter signaling, and cell survival. It is expressed in many different types of neural cells, including dendrites, axons, and glial cells.

The GRIN2D subunit is involved in the regulation of pain perception. It is known that the GRIN2D subunit is involved in the regulation of pain sensitivity and that it can affect the perception of pain. This suggests that targeting this subunit may be a promising new way to treat pain.

The GRIN2D subunit is also involved in neurotransmitter signaling. It is a receptor for the neurotransmitter glutamate and is involved in the regulation of many different types of neurotransmitter signaling. This suggests that targeting this subunit may be a promising new way to treat neurotransmitter-related disorders.

The GRIN2D subunit is also involved in cell survival. It is known that the GRIN2D subunit is involved in the regulation of cell survival and that it can affect the survival of neural cells. This suggests that targeting this subunit may be a promising new way to treat neurodegenerative diseases.

Conclusion

The GRIN2D subunit is a protein that is found in the NMDA receptor. It is made up of 224 amino acids and has a molecular weight of 24.1 kDa. The GRIN2D subunit is involved in many different functions in the CNS, including pain perception, neurotransmitter signaling, and cell survival.

Targeting the GRIN2D subunit is a promising new way to treat many different types of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. It can also be used as a biomarker for diagnosing these diseases.

Protein Name: Glutamate Ionotropic Receptor NMDA Type Subunit 2D

Functions: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750)

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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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