CHST12: Key Enzyme for Connective Tissue Formation and Maintenance

Target Name: CHST12

NCBI ID: G55501

CHST12

CHST12: Key Enzyme for Connective Tissue Formation and Maintenance

Chondroitin 4-sulfotransferase 2 (CHST12) is a protein that is expressed in a variety of tissues in the body, including articular cartilage, tendons, and ligaments. It is a key enzyme in the synthesis of chondroitin, a protein that is involved in the formation of connective tissue. CHST12 is also involved in the breakdown of other proteins and extracellular matrix (ECM) components, which may be important for its role in tissue repair and regeneration.

One of the unique features of CHST12 is its ability to catalyze the transfer of sulfur groups from other proteins to itself. This reaction is known as sulfation, and it allows CHST12 to regulate the levels of sulfur in the connective tissue. In addition, CHST12 is involved in the cross-linking of ECM components, which is important for the stability and strength of tissues.

CHST12 has also been shown to play a role in the regulation of cellular signaling pathways. For example, it has been shown to be involved in the regulation of TGF-β signaling, which is a key pathway involved in cell growth, differentiation, and inflammation. In addition, CHST12 has been shown to play a role in the regulation of the FGF signaling pathway, which is involved in cell growth and differentiation.

In addition to its role in connective tissue synthesis and degradation, CHST12 has also been shown to be involved in the regulation of inflammation. For example, it has been shown to be involved in the production of pro-inflammatory cytokines, such as TNF-伪 and IL-1. In addition, CHST12 has been shown to play a role in the regulation of the immune response, particularly in the regulation of inflammation by T cells.

Given its involvement in a variety of cellular processes, including cell signaling and inflammation, CHST12 may be a promising drug target or biomarker for a variety of diseases. For example, it may be a good candidate for treatment of conditions such as rheumatoid arthritis, which are characterized by inflammation and joint damage. In addition, CHST12 may also be a good candidate for the treatment of other conditions such as cancer, as it has been shown to play a role in the regulation of cell growth and differentiation.

In conclusion, CHST12 is a protein that is involved in a variety of cellular processes, including cell signaling and inflammation. Its unique ability to catalyze the transfer of sulfur groups from other proteins makes it a promising candidate for drug targeting or biomarker development. Further research is needed to fully understand the role of CHST12 in various biological processes and to determine its potential as a drug or biomarker.

Protein Name: Carbohydrate Sulfotransferase 12

Functions: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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