CHST3: A Potential Drug Target for Articular Cartilage Damage

Target Name: CHST3

NCBI ID: G9469

CHST3

CHST3: A Potential Drug Target for Articular Cartilage Damage

Chondroitin 6-O-sulfotransferase 1 (CHST3) is a protein that is expressed in articular cartilage and is involved in the production of chondroitin, a protein that is important for maintaining the mechanical properties of articular cartilage. CHST3 is a potential drug target and has has been identified as a biomarker for various inflammatory and autoimmune diseases.

The CHST3 gene is located on chromosome 12 and encodes a protein that is 61 amino acids long. CHST3 is a member of the superfamily of cysteine-rich proteins (SRP) and is characterized by the presence of a single transmembrane domain and a cytoplasmic tail. CHST3 is expressed in articular cartilage and is involved in the production of chondroitin, which is a protein that plays a crucial role in maintaining the mechanical properties of articular cartilage.

CHST3 is a key enzyme in the production of chondroitin, and it is involved in the first step of the biosynthesis pathway. chondroitin is a highly sulfated protein and is rich in amino acids, which are essential for its structure and function. The sulfation of chondroitin is critical for its ability to interact with other proteins and for its role in maintaining the mechanical properties of articular cartilage.

CHST3 is also involved in the regulation of inflammation and has been identified as a potential drug target for various inflammatory and autoimmune diseases. CHST3 has been shown to play a role in the regulation of pain perception and has been linked to the development of chronic pain conditions.

In addition, CHST3 has also been shown to be involved in the regulation of cellular signaling pathways, including the TGF-β pathway. TGF-β is a well-known signaling pathway that is involved in the regulation of cell growth, differentiation, and inflammation . CHST3 has been shown to play a role in the regulation of TGF-β signaling by modulating the activity of the protein Smad4.

CHST3 is also a good candidate as a biomarker for various diseases, such as rheumatoid arthritis, osteoarthritis, and chronic joint pain. These diseases are characterized by inflammation and wear and tear of the joints, and they cause significant pain and discomfort. CHST3 has has been shown to be expressed in the affected joints and has been linked to the development of these diseases.

In conclusion, CHST3 is a protein that is expressed in articular cartilage and is involved in the production of chondroitin, a protein that plays a crucial role in maintaining the mechanical properties of articular cartilage. CHST3 is also involved in the regulation of inflammation and has been identified as a potential drug target for various inflammatory and autoimmune diseases. Additionally, CHST3 can be used as a biomarker for various diseases, such as rheumatoid arthritis, osteoarthritis, and chronic joint pain. Further research is needed to fully understand the role of CHST3 in these diseases and to develop effective treatments.

Protein Name: Carbohydrate Sulfotransferase 3

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:9714738, PubMed:9883891, PubMed:15215498). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9714738). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:9714738). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity)

The "CHST3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHST3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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