SGPP1: Key Enzyme in Cellular Signaling and Metabolism (G81537)

Target Name: SGPP1

NCBI ID: G81537

SGPP1

SGPP1: Key Enzyme in Cellular Signaling and Metabolism

SGPP1 (Sphingosine-1-Phosphate Phosphatase 1) is a protein that plays a crucial role in cellular signaling and metabolism. It is a key enzyme in the sphingomyelin synapse, which is the structure that transmits signals from the brain to the rest of the body . SGPP1 is also involved in the production of other important signaling molecules, such as ceramide and inositol.

SGPP1 is a protein that is expressed in many different tissues and cells in the body. It is highly conserved, with significant sequence identity across different species. SGPP1 is a single-chain protein that contains 126 amino acid residues. It has a catalytic active site at its N-terminus, which allows it to catalyze the breakdown of sphingomyelin.

SGPP1 is involved in many different cellular processes in the body. One of its most well-known functions is its role in the production of ceramide. Ceramide is a signaling molecule that is involved in a variety of cellular processes, including cell signaling, inflammation, and stress resistance. SGPP1 is the enzyme that catalyzes the production of ceramide from the amino acids lysine and glycine.

Another important function of SGPP1 is its role in the production of inositol. Inositol is a signaling molecule that is involved in a variety of cellular processes, including cell signaling, inflammation, and stress resistance. SGPP1 is the enzyme that catalyzes the production of inositol from the amino acids leucine and lysine.

SGPP1 is also involved in the regulation of cellular signaling pathways. For example, it is has been shown to play a role in the regulation of the Signaling pathway, which is involved in cell signaling. Additionally, SGPP1 is involved in the regulation of the Cellular signaling pathway, which is involved in the transmission of signals from the brain to the rest of the body.

SGPP1 is also a potential drug target. Its role in the production of ceramide and inositol, as well as its involvement in cellular signaling pathways, make it a promising target for drug development. Additionally, its conserved sequence identity across different species makes it a good candidate for small molecule inhibitors.

In conclusion, SGPP1 is a protein that plays a crucial role in cellular signaling and metabolism. It is involved in the production of ceramide and inositol, as well as the regulation of many different cellular signaling pathways. As a result, it is a promising target for drug development and research. Further research is needed to fully understand its functions and potential as a drug.

Protein Name: Sphingosine-1-phosphate Phosphatase 1

Functions: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity)

The "SGPP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SGPP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets