ATP6V1G1P1: A Potential Drug Target and Biomarker for Hydrogen-Transporting Proteins

Target Name: ATP6V1G1P1

NCBI ID: G319116

ATP6V1G1P1

Other Name(s): ATPase H+ transporting V1 subunit G1 pseudogene 1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 1 | ATP6V1GP1

ATP6V1G1P1: A Potential Drug Target and Biomarker for Hydrogen-Transporting Proteins

ATP6V1G1P1, also known as ATPase H+ transporting V1 subunit G1 pseudogene 1, is a gene that encodes a protein involved in the transport of hydrogen ions (H+) in various biological processes. The protein is a key component of the ATPase, a protein-protein interaction that plays a crucial role in regulating various cellular processes, including metabolism, signaling, and cell division. The identification of potential drug targets and biomarkers for this gene has significant implications for the development of new therapeutic strategies for various diseases.

Molecular Structure and Function

ATP6V1G1P1 is a member of the ATPase family, which includes a variety of proteins that play a central role in the transfer of chemical energy from ATP to various cellular processes. The protein encoded by ATP6V1G1P1 is a 21-kDa protein that consists of 118 amino acid residues. It has a unique structure, with a catalytic active site that is known for its stability and specificity.

The protein functions as part of the ATPase subunit G1, which is responsible for the transfer of H+ ions from the cytosol to the mitochondrial matrix. The ATPase is a protein-protein interaction that uses ATP as a source of energy to move the H+ ions across the membrane. The ATPase activity is regulated by various factors, including the concentration of ATP, the availability of other energy sources, and the presence of inhibitors.

Expression and Regulation

ATP6V1G1P1 is highly expressed in various tissues, including muscle, heart, liver, and brain. It is also expressed in various cell types, including epithelial and immune cells. The expression of the protein is regulated by various factors, including gene expression, post-translational modification, and interactions with other proteins.

ATP6V1G1P1 is regulated by several enzymes, including the ATPase enzyme itself. The ATPase enzyme is a G protein-coupled receptor (GPCR), which is known for its role in the regulation of various cellular processes, including cell signaling, cell division, and inflammation. The ATPase enzyme is activated by various agonists, including ATP and FGF, and this activation is regulated by several intracellular signaling pathways, including the PI3K/Akt signaling pathway.

Drug Targets and Biomarkers

The identification of potential drug targets and biomarkers for ATP6V1G1P1 has significant implications for the development of new therapeutic strategies for various diseases. Several studies have suggested that ATP6V1G1P1 may be a potential drug target for various diseases, including heart disease, diabetes, and cancer.

One potential drug target for ATP6V1G1P1 is the use of inhibitors of the ATPase enzyme. These inhibitors would work by binding to the active site of the ATPase enzyme and inhibiting its catalytic activity. This would lead to a reduction in the concentration of ATP and a decrease in the production of H+ ions, which could potentially lead to a variety of therapeutic effects.

Another potential drug target for ATP6V1G1P1 is the use of small molecules that can modulate the activity of the ATPase enzyme. These small molecules could include inhibitors of the ATPase enzyme, as well as modulators of the ATPase-ATP interaction.

Biomarkers

ATP6V1G1P1 has been suggested as a potential biomarker for various diseases, including heart disease, diabetes, and cancer. The levels of ATPase activity in these diseases are often elevated, and this increase in activity could be used as a biomarker

Protein Name: ATPase H+ Transporting V1 Subunit G1 Pseudogene 1

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