ID2: A Potential Drug Target and Biomarker for Helix-Loop-Helix Proteins

Target Name: ID2

NCBI ID: G3398

Content of Review Report on ID2 Target / Biomarker

ID2

ID2: A Potential Drug Target and Biomarker for Helix-Loop-Helix Proteins

Helix-loop-helix (HLH) proteins are a family of non-coding RNAs that play a crucial role in various cellular processes, including DNA replication, repair, and gene regulation. These proteins are known for their unique structure, which consists of a repetitive sequence of nucleotides that forms a \"helix\" when linearized and a \"loop\" when bent, hence their name. ID2 is an HLH protein that has gained significant interest due to its unique structure and function in various cellular processes.

ID2 functions as a negative regulator of the DNA replication process. It plays a vital role in preventing the formation of double-stranded DNA during the G1 phase of cell growth, which is critical for the formation of replicable chromosomes. In addition, ID2 functions as a positive regulator of DNA repair, ensuring that any DNA damage is repaired before the cell divides. This is crucial for maintaining genetic stability and preventing the development of cancer.

ID2 has also been shown to play a role in cell adhesion and migration. It is a critical regulator of the actinin-based cytoskeleton, which is essential for the formation of tight junctions that maintain tissue structure and prevent excessive cell migration. In addition, ID2 is involved in the regulation of cell cycle progression, ensuring that cells divide at the appropriate time and maintain a stable number of chromosomes.

Despite the importance of ID2 in various cellular processes, its functions and potential as a drug target or biomarker remain unexplored. In this article, we will explore the functions of ID2, its unique structure, and its potential as a drug target or biomarker.

Functions of ID2

ID2 is a negative regulator of DNA replication, preventing the formation of double-stranded DNA during the G1 phase of cell growth. This is critical for the formation of replicable chromosomes and ensures that genetic information is accurately passed down from one generation to the next.

In addition to its role in DNA replication, ID2 is also involved in the regulation of DNA repair. DNA repair is a critical process that ensures that any DNA damage is repaired before the cell divides. ID2 functions as a positive regulator of DNA repair, ensuring that any DNA damage is repaired before the cell divides. This is crucial for maintaining genetic stability and preventing the development of cancer.

ID2 has also been shown to play a role in cell adhesion and migration. It is a critical regulator of the actinin-based cytoskeleton, which is essential for the formation of tight junctions that maintain tissue structure and prevent excessive cell migration. In addition, ID2 is involved in the regulation of cell cycle progression, ensuring that cells divide at the appropriate time and maintain a stable number of chromosomes.

Potential as a Drug Target

The unique structure of ID2, with its repetitive sequence of nucleotides that forms a \"helix\" when linearized and a \"loop\" when bent, makes it an attractive drug target. ID2 has been shown to interact with various drug compounds, including inhibitors of the DNA replication complex. This suggests that ID2 may play a role in the regulation of DNA replication and could be a valuable drug target.

In addition to its potential as a drug target, ID2 has also been shown to have potential as a biomarker. The unique structure of ID2 makes it an attractive model for bioinformatics research. By studying the functions of ID2, researchers can gain insights into the mechanisms of DNA replication and repair. This knowledge can be used to develop new diagnostic tools and treatments for various diseases.

Conclusion

In conclusion, ID2 is an HLH protein that plays a crucial role in various cellular processes, including DNA replication, repair, and cell adhesion

Protein Name: Inhibitor Of DNA Binding 2

Functions: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism

The "ID2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ID2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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