IDH1 Gene: Potential Drug Targets and Biomarkers (G3417)

Target Name: IDH1

NCBI ID: G3417

IDH1

IDH1 Gene: Potential Drug Targets and Biomarkers

IDH1 (IDHC-HUMAN), also known as IDH1 gene, is a gene that encodes for a protein known as human interleukin-3 (IL-3). IL-3 is a cytokine that plays a crucial role in the development and maintenance of tissues and organs, including bone marrow, heart, and tissues. It is a key factor in the regulation of cellular processes such as cell growth, differentiation, and inflammation.

IDH1 gene is located on chromosome 18 and encodes for a protein with 191 amino acid residues. The protein produced by the IDH1 gene is a key regulator of the immune system, and has been shown to play a role in the development and progression of various diseases.

One of the most significant functions of IDH1 protein is its role in the regulation of T cell development and function. T cells are a critical part of the immune system, and play a crucial role in fighting off infections and cancer. IDH1 protein is known to be involved in the regulation of T cell receptor (TCR) signaling, which is the process by which T cells recognize and respond to foreign substances in the body.

IDH1 protein has also been shown to play a role in the regulation of cell death and apoptosis. Apoptosis is a natural process that helps remove damaged or dysfunctional cells from the body, and is important for maintaining tissue homeostasis. However, abnormal cell death can contribute to the development and progression of diseases such as cancer. IDH1 protein has been shown to regulate apoptosis by activating the Bcl-2 protein, which promotes the expression of genes involved in cell survival.

IDH1 protein has also been shown to play a role in the regulation of inflammation. Chronic inflammation can contribute to the development and progression of diseases such as heart disease and diabetes. IDH1 protein has been shown to regulate the production of pro-inflammatory cytokines, such as TNF-alpha and IL-12, by suppressing the expression of genes involved in inflammation.

In addition to its role in immune and inflammatory regulation, IDH1 protein has also been shown to play a role in the regulation of cell signaling pathways. IDH1 protein has been shown to interact with a variety of proteins, including TCR, PDGF-1, and NF-kappa-B. These interactions can affect the activity and function of these proteins, and may be important for the regulation of cellular processes such as cell growth, differentiation, and inflammation.

Given its multiple functions in cellular processes, IDH1 protein has potential as a drug target or biomarker. For example, IDH1 has been shown to be involved in the regulation of T cell development and function, which makes it a potential target for drugs that are designed to promote T cell proliferation or enhance their immune response. IDH1 has also been shown to play a role in the regulation of cell death and apoptosis, which makes it a potential target for drugs that are designed to promote cell survival and repair. Finally, IDH1 has been shown to play a role in the regulation of cell signaling pathways, which makes it a potential target for drugs that are designed to affect cellular signaling pathways.

In conclusion, IDH1 (IDHC-HUMAN) is a gene that encodes for a protein with important functions in cellular processes such as immune and inflammatory regulation. Its potential as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for a variety of diseases. Further research is needed to fully understand the functions of IDH1 protein and its potential as a drug target.

Protein Name: Isocitrate Dehydrogenase (NADP(+)) 1

Functions: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)

The "IDH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IDH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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