IFI27: A Potential Drug Target and Biomarker (G3429)

Target Name: IFI27

NCBI ID: G3429

IFI27

IFI27: A Potential Drug Target and Biomarker

Interferonalpha-Inducible Proteins (IFI) are a family of transmembrane proteins that play a crucial role in the regulation of cell growth, differentiation, and immune responses. One of the most well-studied IFI proteins is IFI27, which is expressed in various tissues and cell types and is involved in the regulation of cell proliferation, migration, and survival. In recent years, researchers have identified IFI27 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

IFI27 is a 27-kDa protein that is expressed in various tissues, including the liver, spleen, lung, and pancreas. It is a member of the IFI family, which includes six structurally similar but distinct proteins: IFI1, IFI2, IFI3, IFI4 , IFI5, and IFI6. These proteins share a common extracellular domain, which includes a leucine-rich repeat (LRR), a conserved glycophosphorylated site (GPP), and ac-terminal transmembrane region (TM region). However, IFI27 has unique amino acid acid residues at its C-terminus, which may contribute to its unique function in cell biology.

IFI27 is involved in various cellular processes, including cell growth, apoptosis, and inflammation. One of the most well-studied functions of IFI27 is its role in cell proliferation. IFI27 has been shown to play a positive role in the regulation of cell proliferation, and it has been shown to inhibit the negative effects of the growth factor PDGF on cell proliferation. In addition, IFI27 has been shown to promote the growth of cancer cells, which may contribute to its role in the development of cancer.

IFI27 is also involved in the regulation of cell migration and survival. IFI27 has been shown to play a positive role in the regulation of cell migration and has been shown to interact with the protein FAK (focal adhesion kinase). This interaction may contribute to IFI27's role in the regulation of cell survival and the regulation of cell death.

IFI27 is also involved in the regulation of cellular signaling pathways. IFI27 has been shown to play a positive role in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and growth. In addition, IFI27 has been shown to interact with the protein PD-L1, which is involved in the regulation of immune responses. This interaction may contribute to IFI27's role in the regulation of cellular signaling pathways.

IFI27 is also a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, IFI27 has been shown to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. This overexpression may contribute to the development and progression of these diseases. Additionally, IFI27 has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. This may contribute to its potential as a biomarker for these diseases.

In conclusion, IFI27 is a protein that is involved in various cellular processes and has been shown to play a positive role in the regulation of cell growth, apoptosis, and signaling pathways. Its unique amino acid residues at its C-terminus and its unique function in cell biology may make it a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of IFI27 in cell biology and its potential as a drug target and biomarker.

Protein Name: Interferon Alpha Inducible Protein 27

Functions: Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955)

The "IFI27 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IFI27 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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