IFI16: Key Regulator of Immune Response and Disease (G3428)

Target Name: IFI16

NCBI ID: G3428

IFI16

IFI16: Key Regulator of Immune Response and Disease

IFI16 (IFI16 variant 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the immune response and has been implicated in a number of diseases, including neurodegenerative disorders , autoimmune diseases, and inflammation.

IFI16 is a member of the interferon regulatory factor (IRF) family, which includes a number of proteins that play important roles in the immune response and inflammation. These proteins are characterized by a specific domain that includes a leucine-rich repeat (LRR) and a short amino acid tail.

The IFI16 protein is composed of 214 amino acids and has a molecular weight of 21.1 kDa. It is expressed in a variety of tissues, including the brain, heart, and kidneys, and is highly conserved across different species.

IFI16 has been shown to play a key role in the regulation of the immune response and inflammation. It is a negative regulator of the transcription factor Nrf2, which is involved in the detoxification of environmental toxins and is thought to play a role in the regulation of stress responses. IFI16 has also been shown to regulate the activity of the transcription factor STAT3, which is involved in the regulation of immune responses and cell survival.

IFI16 is also involved in the regulation of inflammation. It is a negative regulator of the transcription factor NF-kappa-B, which is involved in the regulation of inflammatory responses. IFI16 has been shown to inhibit the activity of NF-kappa-B and to play a role in the regulation of the production of pro-inflammatory cytokines.

IFI16 has also been shown to be involved in the regulation of cellular processes that are important for tissue repair and regeneration. It is a positive regulator of the transcription factor PDX1, which is involved in the regulation of wound healing and tissue regeneration. has been shown to play a role in the regulation of the transcription factorFoxO1, which is involved in the regulation of cellular processes that are important for stress responses and DNA damage repair.

IFI16 has been implicated in a number of diseases, including neurodegenerative disorders, autoimmune diseases, and inflammation. For example, studies have shown that IFI16 is involved in the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. IFI16 has also been shown to be involved in the regulation of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Finally, IFI16 has been shown to be involved in the regulation of inflammation, including the regulation of pro-inflammatory cytokine production.

In conclusion, IFI16 is a protein that is involved in a number of important cellular processes that are important for both normal cellular function and the regulation of disease. Its role in the regulation of the immune response and inflammation makes it an attractive target for drug development . Further research is needed to fully understand the mechanisms of IFI16's function and its potential as a drug target.

Protein Name: Interferon Gamma Inducible Protein 16

Functions: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer

The "IFI16 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IFI16 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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