AQP4: A Promising Drug Target for A Variety of Diseases (G361)

Target Name: AQP4

NCBI ID: G361

AQP4

AQP4: A Promising Drug Target for A Variety of Diseases

AQP4 (MIM) is a protein that is expressed in various tissues throughout the body. It is a member of the AQP (aquaporin) family, which are characterized by the presence of a water-binding loop in their extracellular domain. The AQP4 protein has been identified as a potential drug target (MIM) due to its involvement in a variety of physiological processes, including osmosis, cell survival, and signaling.

One of the key functions of AQP4 is its role in osmosis. Osmosis is the process by which cells selectively allow certain substances to enter and exit, while rejecting others. This process is critical for maintaining the integrity of cells and is involved in many physiological processes, including blood pressure, inflammation, and brain function. AQP4 has been shown to play a role in osmosis by regulating the movement of water molecules into and out of cells.

In addition to its role in osmosis, AQP4 is also involved in cell survival and signaling. Studies have shown that AQP4 can interact with various cellular signaling pathways, including the TGF-β pathway. This pathway is involved in many cellular processes, including cell growth, differentiation, and survival. By interacting with this pathway, AQP4 has been shown to promote cell survival and contribute to the regulation of cellular processes that are critical for human health and disease.

Another function of AQP4 is its role in inflammation. Chronic inflammation is a major contributor to many diseases, including heart disease, diabetes, and cancer. AQP4 has been shown to play a role in the regulation of inflammatory processes by promoting the production of pro-inflammatory cytokines. These cytokines can contribute to the recruitment of immune cells to the site of inflammation, which is a critical step in the inflammatory response.

AQP4 has also been shown to play a role in the regulation of many other physiological processes, including cell signaling, cell division, and neurotransmission. It is also involved in the regulation of ion channels, which are critical for the flow of electrical signals through cells.

Given its involvement in a variety of physiological processes, AQP4 is a promising drug target. Studies have shown that inhibiting the activity of AQP4 has the potential to treat a variety of diseases, including cancer, heart disease, and diabetes. In addition, AQP4 has also been shown to be a potential biomarker for a variety of diseases, including cancer and neurodegenerative diseases.

In conclusion, AQP4 is a protein that is involved in a variety of physiological processes and has been identified as a potential drug target. Its role in osmosis, cell survival, and signaling, as well as its involvement in inflammation and other processes, make it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of AQP4 in these processes and to develop safe and effective treatments.

Protein Name: Aquaporin 4

Functions: Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)

The "AQP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AQP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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