KCNA3: Potential Drug Target and Biomarker for Various Diseases

Target Name: KCNA3

NCBI ID: G3738

KCNA3

KCNA3: Potential Drug Target and Biomarker for Various Diseases

KCNA3 (K-type channel alpha-actinin subunit natriuretic peptide receptor 3) is a protein that is expressed in various tissues and cells in the body. It is a member of the natriuretic peptide receptor family 1 (NP receptor family), which is a family of G protein-coupled receptors that play a crucial role in the regulation of water and electrolyte balance in various body systems.

KCNA3 is a 22-kDa protein that is expressed in the heart, kidneys, and other tissues. It is primarily localized to the cytoplasm of the cells in which it is expressed, and it is not known to have any extracellular activity.

KCNA3 is a member of the NP receptor family, which consists of four subfamilies: subfamily A (伪-actinin), subfamily B (尾-actinin), subfamily C (纬-actinin), and subfamily D (未-actinin). Each subfamily of NP receptor has a different natriuretic peptide that is specific for a particular subfamily.

KCNA3 is expressed in various tissues and cells in the body, including the heart, kidneys, liver, pancreas, and cervical uterus. It is primarily localized to the cytoplasm of the cells in which it is expressed, and it is not known to have any extracellular activity.

KCNA3 is a potential drug target in the treatment of various diseases. One of the main reasons for its potential as a drug target is its role in the regulation of water and electrolyte balance. NP receptors are involved in the regulation of water and electrolyte balance by promoting vasodilation and increasing the production of urine. This is important for maintaining the proper balance of water and electrolytes in the body, which is essential for maintaining proper physiological function.

In addition to its role in the regulation of water and electrolyte balance, KCNA3 may also be a potential biomarker for various diseases. For example, altered levels of KCNA3 have been observed in various diseases, including heart failure, hypertension, and diabetes. Additionally, altered levels of KCNA3 have been associated with certain diseases, such as cancer.

Overall, KCNA3 is a protein that is expressed in various tissues and cells in the body. It is a member of the NP receptor family and plays a crucial role in the regulation of water and electrolyte balance in various body systems. As a potential drug target and biomarker, it is worth further research to better understand its role in the regulation of physiological function and its potential as a therapeutic agent.

Protein Name: Potassium Voltage-gated Channel Subfamily A Member 3

Functions: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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