CABL2 as A Potential Drug Target for Neurological Disorders (G81928)

Target Name: CABLES2

NCBI ID: G81928

CABLES2

CABL2 as A Potential Drug Target for Neurological Disorders

CABLES2 (CABL2_HUMAN), a protein that plays a crucial role in the development and maintenance of the blood-brain barrier, has recently been identified as a potential drug target or biomarker for various neurological and psychiatric disorders. The blood-brain barrier is a specialized barrier that separates the brain from the surrounding blood vessels, and it is responsible for maintaining the health and integrity of the brain. However, when this barrier is disrupted or weakened, it can lead to the entry of harmful substances into the brain and the development of various neurological and psychiatric disorders.

CABL2, which stands for CABL2-containing proteins, is a protein that is expressed in various tissues of the body, including the brain. It is a key component of the blood-brain barrier and plays a crucial role in its formation and maintenance. The blood-brain barrier is formed by a tight barrier of endothelial cells, which are specialized cells that line the blood vessels in the brain. This barrier is designed to keep harmful substances out of the brain and to protect the brain from mechanical shocks that could cause injury.

CABL2 is involved in the formation and maintenance of the blood-brain barrier by several mechanisms. Firstly, it is a component of the tight junction, which is a type of cell-cell junction that is formed by the interaction between adjacent cells. The tight junction helps to maintain the integrity of the blood-brain barrier by preventing cells from moving into the space between the blood vessels and the brain.

Secondly, CABL2 helps to regulate the movement of immune cells into the brain. The blood-brain barrier is designed to allow certain types of immune cells to enter the brain in order to help protect the brain from infection and other harmful substances. However, excessive or uncontrolled movement of immune cells into the brain can be harmful and contribute to the development of various neurological and psychiatric disorders. CABL2 helps to regulate this movement by controlling the formation of immune cells that are allowed to enter the brain.

Thirdly, CABL2 is involved in the regulation of the production of new blood vessels in the brain. The blood-brain barrier is designed to prevent new blood vessels from growing in the brain, which is important for the maintenance of the brain's microenvironment and for the delivery of oxygen and nutrients. However, in some cases, the formation of new blood vessels in the brain can be necessary for the development and progression of certain neurological and psychiatric disorders. CABL2 plays a role in regulating the production of new blood vessels in the brain by controlling the formation of blood vessels that are required for the delivery of certain signaling molecules.

In conclusion, CABL2 is a protein that plays a crucial role in the development and maintenance of the blood-brain barrier. Its involvement in the formation and maintenance of the barrier, as well as its involvement in the regulation of immune cell movement and blood vessel formation, makes it a potential drug target or biomarker for various neurological and psychiatric disorders. Further research is needed to fully understand the role of CABL2 in the development and progression of these disorders, as well as to identify potential therapeutic approaches for targeting this protein.

Protein Name: Cdk5 And Abl Enzyme Substrate 2

Functions: Unknown. Probably involved in G1-S cell cycle transition

The "CABLES2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CABLES2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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