CABYR: A Potential Drug Target and Biomarker for Calcium Homeostasis

Target Name: CABYR

NCBI ID: G26256

CABYR

CABYR: A Potential Drug Target and Biomarker for Calcium Homeostasis

Introduction

Calcium homeostasis is a critical regulatory process that plays a vital role in various physiological processes, including muscle contractions, nerve function, and blood clotting. The regulation of calcium homeostasis is often imbalanced, leading to the development of calcium-related disorders, including osteoporosis, epilepsy, and heart disease. The calcium-binding protein (CABYR) is a key protein that has been identified as a potential drug target and biomarker for calcium homeostasis.

CABYR: Structure and Function

CABYR is a 23-kDa protein that is expressed in various tissues, including muscle, nerve, heart, and blood vessels. It is a member of the superfamily of transmembrane proteins, which means that it spans the cell membrane and is involved in various physiological processes. CABYR has a unique feature that consists of a long extracellular domain, a short transmembrane domain, and a short intracellular domain.

The extracellular domain of CABYR consists of a N-terminal region that contains a uniqueGlu-542-Arg loop and a Glu-546-Arg loop. These loops are involved in the formation of a disulfide bond, which is a common feature of proteins that contain disulfide bonds. The transmembrane domain of CABYR consists of a single transmembrane伪-helix. The intracellular domain of CABYR consists of a unique GFP-like region that is involved in the formation of a protein-protein interaction.

CABYR is involved in the regulation of various physiological processes, including calcium homeostasis. It has been shown to play a role in the regulation of muscle contractions, nerve function, and blood clotting. CABYR has also been shown to interact with various calcium ions, including calcium ions from the extracellular environment and intracellular calcium ions.

CABYR as a Potential Drug Target

The regulation of calcium homeostasis is a critical process that is tightly regulated by various factors. Disruptions in this process can lead to the development of various calcium-related disorders, including osteoporosis, epilepsy, and heart disease. The CABYR protein has been shown to be involved in the regulation of calcium homeostasis, and as a potential drug target.

One of the potential strategies for targeting CABYR is to inhibit its activity by using small molecules or antibodies that specifically interact with its active site. This would lead to the inhibition of the regulation of calcium homeostasis by CABYR, which could potentially lead to the development of calcium-related disorders.

CABYR as a Biomarker

CABYR has also been shown to be a potential biomarker for the regulation of calcium homeostasis. The regulation of calcium homeostasis is often monitored by the level of calcium ions in the intracellular environment. CABYR has been shown to interact with intracellular calcium ions, including calcium ions from various signaling pathways, such as calcium ions from neurotransmitters or from the extracellular environment.

Studies have shown that changes in the level of intracellular calcium ions can affect the activity of various physiological processes, including muscle contractions, nerve function, and blood clotting. By monitoring the level of intracellular calcium ions, researchers can study the regulation of calcium homeostasis and the impact of various factors on this process.

Conclusion

CABYR is a protein that has been identified as a potential drug target and biomarker for the regulation of calcium homeostasis. Its unique structure and function, as well as its involvement in the regulation of various physiological processes, make it an attractive target for research and development of new therapies. Further research is needed to fully understand the impact of CABYR on

Protein Name: Calcium Binding Tyrosine Phosphorylation Regulated

Functions: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium

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•   the target screening and validation;
•   expression level;
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