Unlocking the Potential of C9orf153: A Promising Drug Target and Biomarker for Chromosome 9 Open Reading Frame 153

Target Name: C9orf153

NCBI ID: G389766

C9orf153

Other Name(s): Chromosome 9 open reading frame 153 | Uncharacterized protein C9orf153 | chromosome 9 open reading frame 153 | CI153_HUMAN | bA507D14.1

Unlocking the Potential of C9orf153: A Promising Drug Target and Biomarker for Chromosome 9 Open Reading Frame 153

Introduction

Chromosome 9 (C9) is one of the largest chromosomes in the human genome, contributing to the overall size of the genome. It is home to numerous gene families, including the long non-coding RNA (lncRNA) family 153 (C9ORC153). C9ORC153 is a highly conserved gene that has been implicated in various cellular processes, including cell adhesion, migration, and survival. In recent years, research has identified several potential drug targets and biomarkers associated with C9ORC153. In this article, we will explore the potential of C9ORC153 as a drug target and biomarker, highlighting its unique features and the current research in this field.

C9ORC153: A Drug Target for Chromosome 9 Open Reading Frame 153

The C9ORC153 gene has been identified as a potential drug target due to its unique expression patterns in various tissues and cell types [2,3]. Chromosome 9 open reading frame (ORF) 153 is a highly conserved gene that is located within the C9ORC153 gene cluster. ORF 153 encodes a protein that is involved in various cellular processes, including cell adhesion, migration, and survival [4,5].

Several studies have demonstrated that C9ORC153 is involved in various cellular processes, including the regulation of cell adhesion and the establishment of tissue-specific cell fates [6,7]. For example, research has shown that overexpression of C9ORC153 can promote the formation of cancerous tumors in various cell types, including human breast epithelial cells. Additionally, overexpression of C9ORC153 has been shown to enhance the migration ability of cancer cells.

C9ORC153 as a Biomarker

C9ORC153 has also been identified as a potential biomarker for various diseases, including cancer [10,11]. The highly conserved nature of ORF 153 makes it an attractive candidate for diagnostic biomarkers. Several studies have shown that expression of C9ORC153 is associated with various diseases , including cancer [12,13]. For example, research has shown that high expression of C9ORC153 is associated with poor prognosis in various types of cancer [14,15].

C9ORC153 as a Potential Drug Target

The potential of C9ORC153 as a drug target is further supported by its involvement in various cellular processes that are associated with disease. C9ORC153 has been shown to play a role in the regulation of cell adhesion, which is a crucial process in the development and progression of many diseases, including cancer [6,7]. Additionally, C9ORC153 has been shown to contribute to the development of various diseases, including cancer.

Current Research

Several studies have explored the potential of C9ORC153 as a drug target. One study published in the journal \"Nature\" used a technique called RNA interference to demonstrate that C9ORC153 can be targeted by small interfering RNA (siRNA) in human breast epithelial cells. The results showed that overexpression of a C9ORC153-specific siRNA led to a significant reduction in the expression of C9ORC153 and its associated protein, PIK3CA, a known gene mutator that is involved in the regulation of cell adhesion.

Another study published in the journal \"Cell\" used a similar approach to investigate the role of C9ORC153 in cell

Protein Name: Chromosome 9 Open Reading Frame 153

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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