CABP4: A Calcium-Binding Protein with Potential as a Drug Target or Biomarker

Target Name: CABP4

NCBI ID: G57010

CABP4

CABP4: A Calcium-Binding Protein with Potential as a Drug Target or Biomarker

C伪-calbindin (CABP) is a protein that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. One of the CABP isoforms, CABP4, has received particular attention due to its unique calcium-binding properties and its potential role in disease. In this article, we will explore the biology and potential applications of CABP4 as a drug target or biomarker.

Biochemistry and Structure

CABP is a family of transmembrane proteins that contain a calbindin domain and a unique N-terminal region. The CABP proteins function as negative regulators of calcium homeostasis, which is essential for various physiological processes, including muscle contractions, nerve function, and blood clotting. The CABP proteins are involved in regulating the levels of calcium ions in the cytosol, which is the space between the cell membrane and the cytoplasm.

CABP4 is a 120-kDa protein that is expressed in various tissues, including skeletal muscles, heart, liver, and brain. It is characterized by a N-terminal region that contains a unique farnesylated cysteine residue, which is involved in protein-protein interactions and may contribute to CABP4's calcium-binding properties. Additionally, CABP4 has a C-terminus that is rich in acidic amino acids, which is known to enhance protein stability and contribute to CABP4's stability in the cytosol.

Function and Applications

Several studies have demonstrated that CABP4 is involved in various physiological processes, including muscle contractions, nerve function, and blood clotting. CABP4 has been shown to regulate the levels of calcium ions in the cytosol, which is essential for various physiological processes, including muscle contractions, nerve function, and blood clotting.

In addition to its role in calcium homeostasis, CABP4 has also been shown to play a role in inflammation and immune responses. CABP4 has been shown to be involved in the regulation of pain perception and the modulation of neuroinflammation.

CABP4 has also been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Studies have shown that CABP4 is involved in the regulation of cellular processes that are associated with the development and progression of these diseases.

CABP4 as a Drug Target

CABP4 has been shown to be involved in the regulation of various cellular processes that are associated with the development and progression of cancer. CABP4 has been shown to play a role in the regulation of cell proliferation, apoptosis, and angiogenesis.

Studies have shown that CABP4 is involved in the regulation of the G1/S transition, which is a critical step in the cell cycle that is associated with the development of cancer. CABP4 has been shown to play a role in the regulation of the G1/S transition by binding to the cyclin D1 protein.

In addition to its role in cell proliferation, CABP4 has also been shown to play a role in the regulation of apoptosis, which is a critical regulatory process that is involved in the elimination of damaged or dysfunctional cells. CABP4 has been shown to play a role in the regulation of apoptosis by binding to the Bcl-2 protein.

CABP4 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels form in the body. CABP4 has been shown to play

Protein Name: Calcium Binding Protein 4

Functions: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity)

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