TNFAIP8L3: A Potential Drug Target and Biomarker (G388121)

Target Name: TNFAIP8L3

NCBI ID: G388121

TNFAIP8L3

Other Name(s): TNFAIP8-like protein 3 | tumor necrosis factor, alpha induced protein 8 like 3 | Tumor necrosis factor alpha-induced protein 8-like protein 3 | TNF alpha induced protein 8 like 3 | FLJ41287 | TNF alpha-induced protein 8-like protein 3 | Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3) | TNF alpha induced protein 8 like 3, transcript variant 1 | TIPE3 | Tumor necrosis factor alpha-induced protein 8-like protein 3 (isoform 1) | Tumor necrosis factor, alpha-induced protein 8-like protein 3 | TP8L3_HUMAN

TNFAIP8L3: A Potential Drug Target and Biomarker

Introduction

Tumor necrosis factor-alpha-induced intracellular signaling (TNFAIP8L3) is a protein that has been identified as a potential drug target and biomarker in various diseases, including cancer. This protein plays a crucial role in the regulation of cellular processes, including cell death, inflammation, and autophagy.tnfaip8L3 functions as a negative regulator of the tumor necrosis factor-alpha (TNF-伪) signaling pathway, which is a well-established mediator of cancer progression.

The TNFAIP8L3 Protein

TNFAIP8L3 is a 21-kDa protein that is expressed in various cell types, including cancer cells, immune cells, and normal tissues. It is composed of two major domains: an N-terminal transmembrane domain and a C-terminal cytoplasmic domain. The N -terminal domain contains a putative G protein-coupled receptor (GPCR) domain, which is responsible for the protein's interactions with ligands, such as TNF-伪. The C-terminal domain contains a unique structural domain, known as the TNFAIP8L3-specific domain , which is involved in the regulation of the TNF-伪 signaling pathway.

TNFAIP8L3's Functions in Cellular Processes

TNFAIP8L3 is involved in the regulation of various cellular processes, including cell death, inflammation, and autophagy. In cancer cells, TNFAIP8L3 plays a crucial role in the regulation of cell survival and the maintenance of cancer cell proliferation.

In cell death, TNFAIP8L3 is involved in the regulation of cell apoptosis, which is a critical mechanism that helps to eliminate damaged or dysfunctional cells. During apoptosis, TNFAIP8L3 plays a role in the production and presentation of programmed cell death (PD-1) signals , which are necessary for the efficient elimination of cancer cells.

In inflammation, TNFAIP8L3 is involved in the regulation of pro-inflammatory responses and the production of anti-inflammatory responses. The cytoplasmic domain of TNFAIP8L3 contains a unique structural domain, known as the inflammasome-associated protein (IP3) domain, which is involved in the production of pro-inflammatory cytokines, such as IL-1尾 and IL-18. These cytokines contribute to the regulation of immune responses and tissue inflammation.

In autophagy, TNFAIP8L3 is involved in the regulation of cellular autophagy, which is the process by which cells break down and recycle damaged or unnecessary cellular components. The cytoplasmic domain of TNFAIP8L3 contains a unique structural domain, known as theBeclin-1 (Bec-1 ) domain, which is involved in the regulation of autophagy.

Potential Drug Target and Biomarker

TNFAIP8L3 has been identified as a potential drug target and biomarker due to its involvement in various diseases, including cancer. The TNFAIP8L3 protein is a negative regulator of the TNF-伪 signaling pathway, which is a well-established mediator of cancer progression. Therefore, Compounds that can inhibit the activity of TNFAIP8L3 may have potential therapeutic applications in cancer treatment.

In addition to its potential therapeutic applications, TNFAIP8L3 has also been identified as a potential biomarker for various diseases, including cancer. The production of TNFAIP8L3 is regulated by various factors, including its expression level, localization to specific cellular compartments, and interactions with other proteins . Therefore, changes in the expression or localization of TNFAIP8L3 may be an indicator of certain diseases.

Conclusion

TNFAIP8L3 is a protein that has been identified as a potential drug target and biomarker in various diseases, including cancer. Its functions in

Protein Name: TNF Alpha Induced Protein 8 Like 3

Functions: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling

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