TNFRSF12A: A Potential Drug Target and Biomarker (G51330)

Target Name: TNFRSF12A

NCBI ID: G51330

TNFRSF12A

TNFRSF12A: A Potential Drug Target and Biomarker

Introduction

Fibroblast growth factor-inducible immediate-early response protein 14 (TNFRSF12A) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique mechanism of regulation, as well as its involvement in several cellular processes, makes it an attractive target for drug development.

Molecular Mechanism

TNFRSF12A is a member of the TNFRSF family, which includes several transcription factor receptor proteins, such as TNFRSF1, TNFRSF2, and TNFRSF5. These receptor proteins play important roles in a variety of physiological and pathological processes. TNFRSF12A is a transmembrane protein whose encoding gene is 14 kDa.

The expression and function of TNFRSF12A can be studied through a variety of experimental methods, including Western blotting, immunohistochemistry, co-transfection, co-precipitation, and gene knockout techniques. Studies have shown that TNFRSF12A is expressed in a variety of tissues and organs, and its expression level is closely related to the occurrence and development of various diseases.

Pharmacological properties

TNFRSF12A, as a drug target, has various pharmacological properties. First, TNFRSF12A is a ligand-binding receptor that can bind to a variety of ligands, including drug molecules and intracellular molecules. Secondly, TNFRSF12A has a variety of regulatory mechanisms, such as negative feedback, positive feedback and phosphorylation, etc. These mechanisms can affect its own phosphorylation level, thereby affecting its function. Finally, the expression level of TNFRSF12A can be regulated in a variety of ways, including gene expression, RNA binding, and protein modification.

biological significance

The role and dysregulation of TNFRSF12A in various diseases have been extensively studied. For example, knockdown of TNFRSF12A can significantly inhibit tumor growth, while overexpression of TNFRSF12A can promote tumor growth. In addition, TNFRSF12A is also closely related to a variety of neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease.

As a drug target, TNFRSF12A has various pharmacological properties and biological significance. With the deepening of research, TNFRSF12A will become an important drug target and provide new ideas and strategies for the treatment of various diseases.

Protein Name: TNF Receptor Superfamily Member 12A

Functions: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins

The "TNFRSF12A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TNFRSF12A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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