LAIR1: A Potential Drug Target and Biomarker (G3903)

Target Name: LAIR1

NCBI ID: G3903

LAIR1

LAIR1: A Potential Drug Target and Biomarker

LAIR1, short for LDL-R1- associated receptor 1, is a protein that is expressed in various tissues throughout the body, including the liver, muscle, and brain. It is a member of the superfamily of G protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are known for their ability to modulate a wide range of physiological processes, including inflammation, neurotransmission, and ion channels.

The discovery of LAIR1 and its potential function as a drug target or biomarker has significant implications for the development of new treatments for a variety of diseases. While the exact mechanism of how LAIR1 functions is not yet fully understood, research has shown that it is involved in the regulation of cellular processes that are critical for human health and disease.

One of the key functions of LAIR1 is its role in the regulation of lipid metabolism. Lipids are an essential component of the body and are crucial for maintaining cellular health and function. However, an imbalance in lipid metabolism can lead to the development of diseases such as cardiovascular disease and diabetes.

LAIR1 has been shown to play a critical role in the regulation of lipid metabolism by modulating the expression of genes involved in lipid metabolism. Studies have shown that LAIR1 can interact with various cellular signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular processes that are critical for the production and uptake of lipids, such as lipoproteins and triglycerides.

In addition to its role in lipid metabolism, LAIR1 has also been shown to play a critical role in the regulation of cellular processes that are critical for human health and disease. For example, studies have shown that LAIR1 is involved in the regulation of cellular processes that are involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

The potential drug targets for LAIR1 are vast, and there is significant interest in developing new treatments for a variety of diseases that are associated with LAIR1 dysfunction. One of the key challenges in developing new treatments for LAIR1-related diseases is understanding the precise mechanism of how LAIR1 functions and how it can be targeted with small molecules.

In conclusion, LAIR1 is a protein that is involved in the regulation of various cellular processes that are critical for human health and disease. Its potential as a drug target and biomarker makes it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the precise mechanism of LAIR1 and develop effective treatments for its dysfunction.

Protein Name: Leukocyte Associated Immunoglobulin Like Receptor 1

Functions: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells

The "LAIR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LAIR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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