LAMTOR2: A Protein Involved in Endosomal System and Intracellular Signaling Pathways

Target Name: LAMTOR2

NCBI ID: G28956

LAMTOR2

LAMTOR2: A Protein Involved in Endosomal System and Intracellular Signaling Pathways

LAMTOR2 (endosomal adapter protein p14) is a protein that is expressed in various tissues throughout the body, including the brain, spleen, and gastrointestinal tract. It is a member of the adapter protein family, which includes proteins that play a crucial role in the intracellular transport of various molecules, including vesicles and organelles.

One of the unique features of LAMTOR2 is its ability to interact with various intracellular structures, including the endosomal system. The endosomal system is a complex network of organelles that are involved in the delivery of intracellular vesicles, including viruses, malware, and other pathogens. LAMTOR2 has been shown to interact with various endosomal proteins, including the vesicular protein transmembrane protein (Tpm) and the viral particle-associated protein (VAP).

This interaction between LAMTOR2 and Tpm is of particular interest, as Tpm is known to play a key role in the delivery of viruses to the endoplasmic reticulum (ER), where they are then processed and degraded by the endoplasmic reticulum-associated degradation pathway (ERAD ). LAMTOR2's interaction with Tpm may suggest that it could be a drug target or biomarker for interventions aimed at modulating the endosomal system.

In addition to its interaction with Tpm, LAMTOR2 has also been shown to interact with several other intracellular structures, including the cytoskeleton, the endoplasmic reticulum, and the peroxisome. These interactions may be of particular interest in the context of diseases that involve disruptions in the normal function of these structures, such as neurodegenerative diseases and diseases of the gastrointestinal tract.

Another potential mechanism by which LAMTOR2 may be involved in disease is its role in the regulation of cellular signaling pathways. LAMTOR2 has been shown to interact with several intracellular signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the NF-kappa-B signaling pathway. These interactions may suggest that LAMTOR2 plays a role in the regulation of cellular processes that are involved in the development and progression of a wide range of diseases.

In conclusion, LAMTOR2 is a protein that has significant interactions with various intracellular structures, including the endosomal system. These interactions suggest that LAMTOR2 may be a drug target or biomarker for interventions aimed at modulating the endosomal system and its role in the regulation of cellular signaling pathways. Further research is needed to fully understand the mechanisms by which LAMTOR2 is involved in disease.

Protein Name: Late Endosomal/lysosomal Adaptor, MAPK And MTOR Activator 2

Functions: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2

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•   general information;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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