OR4C45: A Potential Drug Target and Biomarker (G403257)

OR4C45: A Potential Drug Target and Biomarker

OR4C45, a member of the Olfactory Receptor (OR) family, is a G protein-coupled receptor (GPCR) that is expressed in the olfactory system of the human body. OR4C45 is involved in the sense of smell and is one of the six subtypes of the OR family. It is characterized by its long, N-terminal extracellular domain, which contains a putative intracellular signaling pathway that involves the cAMP/protein kinase (PKA) signaling pathway.

GPCRs are a family of transmembrane proteins that play an important role in cellular signaling. They are involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. OR4C45 is one of the most well-studied GPCRs, and its function in the olfactory system has been extensively investigated.

OR4C45 is involved in the detection of volatile organic compounds (VOCs), which are molecules that are emitted by bacteria and other microorganisms. In the olfactory system, VOCs are detected by specialized neurons called olfactory epithelial cells (olfactory epithelial cells), which are located in the nasal cavity. These neurons are responsible for transmitting the sense of smell to the brain.

OR4C45 is a GPCR that is expressed in the olfactory system, and its function in this system is to detect VOCs and initiate the olfactory response. OR4C45 is highly selective for certain VOCs, such as ammonia, acetone, and methane. It is also known to be involved in the regulation of the olfactory response, including the delay of the onset of the olfactory signal.

In addition to its role in the olfactory system, OR4C45 is also a potential drug target. Several studies have suggested that OR4C45 may be a useful target for the development of new treatments for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and chronic insomnia.

One reason for the potential utility of OR4C45 as a drug target is its involvement in the PKA signaling pathway. PKA is a well-established mediator of GPCR signaling, and it is involved in the regulation of a wide range of physiological processes, including sensory perception and neurotransmission.

Studies have suggested that OR4C45 may be involved in the regulation of PKA signaling in the olfactory system. For example, several studies have shown that OR4C45 is involved in the regulation of PKA activity in the olfactory system, including the modulation of PKA signaling by certain VOCs.

Additionally, OR4C45 has been shown to play a role in the regulation of neurotransmission in the olfactory system. For example, studies have shown that OR4C45 is involved in the regulation of neurotransmitter release from the olfactory neurons, including the neurotransmitter serotonin.

Another potential mechanism by which OR4C45 may be involved in drug targeting is its role in the regulation of sleep-wake cycles. Studies have shown that OR4C45 is involved in the regulation of sleep-wake cycles in the olfactory system, including the control of the duration of sleep periods and the regulation of the production of wakefulness.

The potential utility of OR4C45 as a drug target is based on its involvement in the regulation of various physiological processes, including sensory perception, neurotransmission, and sleep-wake cycles. Further research is needed to fully understand the role of OR4C45 in these processes and to develop new treatments based on this understanding.

In conclusion, OR4C45 is a GPCR that is involved in the detection of VOCs in the olfactory system and is a potential drug target. Its involvement in the regulation of PKA signaling, neurotransmission, and sleep-wake cycles makes it a promising target for the development of new treatments for a wide range of neurological and psychiatric disorders. Further research is needed to fully understand the role of OR4C45 in these processes and to develop new treatments based on this understanding.

Protein Name: Olfactory Receptor Family 4 Subfamily C Member 45 (gene/pseudogene)

Functions: Odorant receptor

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•   general information;
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•   the target screening and validation;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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