MTIF2: A Potential Drug Target for Placenta-Derived Diseases (G4528)

Target Name: MTIF2

NCBI ID: G4528

MTIF2

MTIF2: A Potential Drug Target for Placenta-Derived Diseases

MTIF2 (IF-2(Mt)) is a protein that is expressed in the human placenta and has been shown to play a role in the development and progression of various diseases, including cancer. Its function and significance have led it to be considered as a potential drug target or biomarker.

The Placenta plays a vital role in the development and maintenance of fetal life, and it is a complex organ that is responsible for providing the growing fetus with the necessary nutrients and oxygen. The placenta is also the site of many important biological processes that help to regulate the development of the fetus, including the regulation of cell growth and apoptosis. MTIF2 is one of the proteins that is expressed in the placenta and has been shown to be involved in these processes.

MTIF2 is a member of the IMP (Inositol-Mannoside) family, which is a group of transmembrane proteins that are characterized by the presence of an inositol molecule in their extracellular region. This family of proteins includes several different isoforms, including IMP1, IMP2, and IMP3, which are expressed in various tissues and organs throughout the body.

MTIF2 is primarily expressed in the placenta, with lower levels of expression found in other tissues such as the liver, lung, and brain. It is a 14-kDa protein that has a molecular weight of approximately 17 kDa. MTIF2 is localized to the endoplasmic reticulum (ER) and can be internalized by endoplasmic reticulum (ER) transcribed splicing proteins (ERTSPs), which are responsible for the translation of mRNAs from the ER to the plasma membrane. Once internalized, MTIF2 is retained in the ER and is not accessible to the cytosol, which limits its ability to interact with other proteins.

MTIF2 has been shown to play a role in the regulation of various biological processes that are critical for fetal development and growth. One of its most well-studied functions is its role in the regulation of cell apoptosis. Apoptosis is a natural process that is involved in the elimination of damaged or dysfunctional cells in the body, and it is a critical aspect of fetal development and growth. MTIF2 has been shown to be involved in the regulation of apoptosis by promoting the production of pro-apoptotic transcription factors (TFs), such as Bax and p53.

In addition to its role in apoptosis, MTIF2 has also been shown to be involved in the regulation of cell growth and cell cycle progression. It has been shown to play a role in the regulation of G1 checkout, which is the stage of the cell cycle where growth and proliferation are highly regulated. MTIF2 has been shown to promote the growth of cells by inhibiting the activity of the protein p21, which is a negative regulator of the G1 checkout stage.

MTIF2 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed in the body. Angiogenesis is a critical aspect of fetal development and is required for the proper delivery of oxygen and nutrients to the developing fetus. MTIF2 has been shown to play a role in the regulation of angiogenesis by promoting the production of pro-angiogenic factors, such as VEGF.

In conclusion, MTIF2 is a protein that is expressed in the placenta and has been shown to play a role in the development and progression of various diseases, including cancer. Its function and significance have led it to be considered as a potential drug target or biomarker. Further studies are needed to fully understand the role of MTIF2 in these processes and to develop new treatments for diseases associated with its dysfunction.

Protein Name: Mitochondrial Translational Initiation Factor 2

Functions: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex

The "MTIF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTIF2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets