NFATC4: Key Regulator of T-Cell Development and Function (G4776)

Target Name: NFATC4

NCBI ID: G4776

NFATC4

NFATC4: Key Regulator of T-Cell Development and Function

NFATC4, also known as Cytoplasmic nuclear factor of activated T-cells 4, is a protein that plays a crucial role in the regulation of T-cell development and function. It is a key transcription factor that is involved in the development and activation of CD4+ T-cells, which are a vital part of the immune system.

NFATC4 is a cytoplasmic protein that is expressed in various tissues, including the spleen, thymus, spleen lymph nodes, and Peyer's patches. It is a 22kDa protein that consists of 214 amino acid residues. The protein has a nuclear localization and is involved in the regulation of gene expression.

NFATC4 is a key transcription factor that is involved in the development and activation of CD4+ T-cells. It is essential for the survival and proliferation of CD4+ T-cells, and it plays a crucial role in the regulation of their functional properties.

One of the most significant functions of NFATC4 is its ability to promote the development and activation of CD4+ T-cells. CD4+ T-cells are a vital part of the immune system and play a crucial role in the regulation of immunity and inflammation. They are responsible for the production of antibodies, cytokines, and other immune molecules that help to protect the body against infection and disease.

NFATC4 is involved in the regulation of CD4+ T-cell development and activation by promoting the expression of genes that are necessary for T-cell development and activation. It is also involved in the regulation of the cytolytic death of CD4+ T-cells, which is a process that is necessary for their proper functioning and contributes to their survival.

Another important function of NFATC4 is its role in the regulation of immune cell function. T-cells are a vital part of the immune system and play a crucial role in the regulation of immunity and inflammation. NFATC4 is involved in the regulation of T-cell function by promoting the expression of genes that are necessary for T-cell activation, proliferation, and differentiation.

NFATC4 is also involved in the regulation of inflammation and immune cell function. It is involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha, by promoting the expression of genes that are necessary for their production. It is also involved in the regulation of the production of anti-inflammatory cytokines, such as IL-10, by promoting the expression of genes that are necessary for their production.

In conclusion, NFATC4 is a protein that plays a crucial role in the regulation of T-cell development and function. It is a key transcription factor that is involved in the development and activation of CD4+ T-cells, and it is involved in the regulation of CD4+ T-cell function, immune cell function, and inflammation. As a result, NFATC4 may be a potential drug target or biomarker for the treatment of various diseases.

Protein Name: Nuclear Factor Of Activated T Cells 4

Functions: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity)

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•   protein biological mechanisms;
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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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