CCDC73: A Potential Drug Target and Biomarker (G493860)

Target Name: CCDC73

NCBI ID: G493860

CCDC73

CCDC73: A Potential Drug Target and Biomarker

Introduction

CDC73, also known as coiled-coil domain containing 73, is a protein that has been identified as a potential drug target and biomarker. It is a key component of the intracellular signaling pathway known as the TGF-β pathway, which plays a crucial role in cell growth, differentiation, and survival. The TGF-β pathway is a well-established target for numerous diseases, including cancer, and therefore, researchers are actively searching for new drug targets and biomarkers. CCDC73 is one of the potential drug targets that has received significant interest due to its unique biology and the potential impact it could have on human health.

CDC73: Structure and Function

CDC73 is a protein that is expressed in various tissues and cells, including muscle, nerve, heart, and cancer cells. It is composed of a unique structure that consists of a catalytic domain, a transmembrane region, and an intracellular loop. The catalytic domain is the site of the protein's catalytic activity, while the transmembrane region is responsible for its stability and functions as a receptor. The intracellular loop is a structural element that plays a critical role in the regulation of the TGF-β pathway.

The TGF-β pathway is a well-established signaling pathway that is involved in the regulation of cell growth, differentiation, and survival. It is activated by the presence of growth factors, such as TGF-β1, which is a potent ligand for the pathway. Once activated, the TGF-β pathway promotes the formation of new cells, including neurons and tissues, and regulates the differentiation of cells into specific cell types.

CDC73 is a key component of the TGF-β pathway because of its role in the regulation of the pathway's activity. It is composed of a unique structure that allows it to interact with and regulate the activity of other proteins that are involved in the TGF- 尾 pathway. Specifically, CDC73 is involved in the regulation of the activity of the transcription factor, SMAD, which is a key regulator of the TGF-β pathway.

CDC73 has been shown to play a critical role in the regulation of TGF-β pathway activity in various tissues and cells. For example, studies have shown that CDC73 can inhibit the activity of SMAD, which is a critical transcription factor that regulates the TGF- 尾 pathway. This inhibition of SMAD activity by CDC73 has been shown to promote the formation of new tissues, including neural cells, in animal models of neurodegenerative diseases.

In addition to its role in the regulation of TGF-β pathway activity, CDC73 has also been shown to play a critical role in the regulation of cell growth and differentiation. For example, studies have shown that CDC73 can inhibit the activity of the oncogene, p53, which is a well-established regulator of cell growth and apoptosis. This inhibition of p53 activity by CDC73 has been shown to promote the growth and survival of cancer cells, which are a major concern in the development of various diseases.

CDC73: Potential Drug Target

The potential drug target for CDC73 is based on its role in the regulation of the TGF-β pathway and its involvement in the regulation of cell growth and differentiation. Drugs that can inhibit the activity of CDC73 and/or its downstream targets have the potential to be useful therapies for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the potential drug targets for CDC73 is the inhibition of SMAD, which is a critical transcription factor that regulates the TGF-β pathway. This can be achieved through the use of small molecules, such as inhibitors of DNA-binding proteins, which can inhibit the

Protein Name: Coiled-coil Domain Containing 73

The "CCDC73 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCDC73 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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