Understanding OR10A3: A GPCR That Controls Olfactory Sensitivity
Understanding OR10A3: A GPCR That Controls Olfactory Sensitivity
Olfactory receptor, family 10, subfamily A, member 3 (OR10A3) is a protein that plays a crucial role in human sensory function. OR10A3 is a G protein-coupled receptor (GPCR), which means it is a transmembrane protein that spans the cell membrane and interacts with extracellular ligands. OR10A3 is expressed in the olfactory epithelial cells, which line the olfactory cavity, and it is involved in the sense of smell.
OR10A3 is composed of an extracellular portion, a transmembrane portion, and an intracellular portion. The extracellular portion of OR10A3 is made up of a long, N-terminal region that contains a putative receptor tyrosine kinase (RTK) domain. This region is responsible for the interaction with extracellular ligands, such as neurotransmitters that activate the GPCR.
The transmembrane portion of OR10A3 is made up of a single transmembrane protein that spans the entire length of the cell membrane. This portion contains a putative GPCR domain, as well as a putative C-type tyrosine kinase (TK) domain. The C-type tyrosine kinase domain is responsible for the catalytic activity of the GPCR, while the TK domain is involved in the regulation of the activity of the GPCR.
The intracellular portion of OR10A3 is made up of a single protein that contains a putative GPCR domain and a putative GRP-尾 (G protein-coupled receptor-尾) domain. The GRP-尾 domain is a subunit of the GPCR that is involved in the regulation of the activity of the GPCR.
OR10A3 is involved in the sense of smell because it is a critical receptor for the neurotransmitter olfactory neurotransmitter (ON-Q), which is responsible for the sensation of smell. OR10A3 is also involved in the regulation of the activity of other GPCRs, including the GPCR that mediates pain perception.
Due to its involvement in the sense of smell and its potential as a drug target, OR10A3 has received a great deal of interest in recent years. Researchers have identified several potential drug candidates that can inhibit the activity of OR10A3 and enhance its activity. These drug candidates include small molecules, peptides, and proteins.
One of the most promising drug candidates for OR10A3 is a small molecule called 4-[(2-methylphenyl)amino]-7-nitro-2,1,3-benzoxadiazole (MPA). MPA is a potent inhibitor of OR10A3, and it has been shown to enhance the activity of other GPCRs, including OR10A1 and OR11A1. MPA works by binding to the RTK domain of OR10A3 and inhibiting its activity.
Another potential drug candidate for OR10A3 is a peptide called P1. P1 is a 21-amino acid peptide that contains a conserved core region that is similar to the extracellular region of OR10A3. P1 has been shown to enhance the activity of OR10A3 and to interact with the GRP-尾 domain of OR10A3.
In addition to these drug candidates, researchers have also identified several other proteins that are involved in the regulation of OR10A3. These proteins include the neurotransmitter GABA, which is involved in the regulation of pain perception, and the protein
Protein Name: Olfactory Receptor Family 10 Subfamily A Member 3
Functions: Odorant receptor
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More Common Targets
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