ACOX1: A Potential Drug Target for Disabilities and Diseases (G51)

Target Name: ACOX1

NCBI ID: G51

ACOX1

ACOX1: A Potential Drug Target for Disabilities and Diseases

ACOX1 (Straight-chain acyl-CoA oxidase) is a protein that is expressed in various tissues throughout the body, including the liver, muscle, and heart. It is a key enzyme in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle, which is a central metabolic pathway that generates energy in the form of ATP from food molecules.

ACOX1 is a proton pump, which means it uses ATP to pump protons across the membrane. This pump mechanism allows the enzyme to function as a critical player in the citric acid cycle, as it helps to regulate the flow of electrons and protons across the membrane. The encoded gene for ACOX1 has been identified and its function has been extensively studied.

ACOX1 is a potential drug target or biomarker due to its involvement in the citric acid cycle and its potential role in the development and progression of various diseases. Several studies have suggested that alterations in ACOX1 expression levels or activity levels may be involved in the development of certain diseases, including cancer, cardiovascular disease, and neurological disorders.

One of the main potential benefits of targeting ACOX1 is its potential to inhibit the production of reactive oxygen species (ROS) that can damage cellular components and contribute to the development of various diseases. ROS are generated by processes such as metabolism and cellular stress, and they can interact with other cellular components to cause damage. Some studies have suggested that ACOX1 may be involved in the production of ROS, and that inhibiting its activity may be a potential strategy for targeting diseases that are caused by the production of ROS.

Another potential benefit of targeting ACOX1 is its potential to modulate cellular signaling pathways. ACOX1 is a key enzyme in the citric acid cycle, and it is involved in the production of ATP, which is a critical signaling molecule. Some studies have suggested that alterations in ACOX1 expression levels or activity levels may be involved in the regulation of cellular signaling pathways, and that targeting these pathways may be a potential strategy for the development of new therapeutics for various diseases.

Targeting ACOX1 may also be a potential strategy for treating certain diseases that are caused by the production of ROS. ROS can interact with other cellular components to cause damage, and some diseases are caused by the production of ROS that can damage the brain, heart, and other tissues. Targeting ACOX1 may be a potential strategy for inhibiting the production of ROS and reducing the production of reactive oxygen species, which can help to treat these diseases.

In conclusion, ACOX1 is a key enzyme in the citric acid cycle that is involved in the production of ATP and the regulation of cellular signaling pathways. Its involvement in these processes makes it a potential drug target or biomarker, and its potential to inhibit the production of ROS makes it a potential strategy for the development of new therapeutics for various diseases. Further research is needed to fully understand the role of ACOX1 in the development and progression of diseases, as well as its potential as a drug target or biomarker.

Protein Name: Acyl-CoA Oxidase 1

Functions: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:7876265, PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:7876265, PubMed:17458872, PubMed:17603022)

The "ACOX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACOX1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets