GINS2: A Potential Drug Target and Biomarker (G51659)

Target Name: GINS2

NCBI ID: G51659

GINS2

GINS2: A Potential Drug Target and Biomarker

GINS2 (GINS complex subunit 2) is a protein that is expressed in various tissues and cells throughout the body. It is a key component of the GINS complex, a protein-protein interaction network that plays a critical role in various cellular processes, including cell signaling, gene regulation, and disease development. The GINS complex has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

GINS2 functions as a negative regulator of the Runx1a gene, which is a key regulator of stem cell proliferation and differentiation. The GINS2-Runx1a interaction has been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and angiogenesis. GINS2 has also been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway, which is involved in cell signaling, tissue repair, and regeneration.

GINS2 has also been shown to be involved in the regulation of gene expression and DNA replication. It has been shown to interact with various transcription factors, including NF-kappa-B, AP-1, and STAT3, to regulate their activity and contribute to the regulation of cellular processes such as cell growth, apoptosis, and chromatin structure. GINS2 has also been shown to play a role in the regulation of DNA replication, including the replication of the ADHD gene, which is associated with neurodevelopmental disorders.

In addition to its role in cellular signaling and gene regulation, GINS2 has also been shown to play a role in the regulation of cellular adhesion. It has been shown to interact with various adhesion molecules, including cadherin and E-cadherin, to regulate their activity and contribute to the regulation of cellular adhesion and tissue organization. GINS2 has also been shown to play a role in the regulation of cell-cell adhesion, which is important for the maintenance of tissue structure and the development of tissues.

GINS2 has also been shown to be involved in the regulation of inflammation and immune response. It has been shown to interact with various immune cell types, including T cells and macrophages, to regulate their activity and contribute to the regulation of cellular immunity. GINS2 has also been shown to play a role in the regulation of inflammatory responses, including the regulation of inflammation and the production of pro-inflammatory cytokines.

In conclusion, GINS2 is a protein that has been shown to play a critical role in various cellular processes that are important for the regulation of health and disease. Its function as a negative regulator of the Runx1a gene and its involvement in the regulation of cellular signaling pathways, gene expression, DNA replication, and cellular adhesion make it a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of GINS2 in the regulation of cellular processes and its potential as a drug target.

Protein Name: GINS Complex Subunit 2

Functions: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)

The "GINS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GINS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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