Overview of PITPNM3: Potential Drug Target Or Biomarker (G83394)

Target Name: PITPNM3

NCBI ID: G83394

PITPNM3

Overview of PITPNM3: Potential Drug Target Or Biomarker

PITPNM3 (PITM3_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is a member of the PITIN family, which includes proteins that are involved in the regulation of intracellular signaling pathways. Despite its importance in cellular signaling, little is known about PITPNM3 and its function in the human body.

PURPOSE OF THE ARTICLE

The purpose of this article is to provide an overview of PITPNM3, including its structure, expression, and potential functions as a drug target or biomarker. This article will focus on the biological significance of PITPNM3 and its potential as a therapeutic target for various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

Structure and Expression

PITPNM3 is a 21-kDa protein that is expressed in a variety of tissues in the human body, including the brain, heart, and blood vessels. It is highly conserved across different species, with the highest sequence identity between human and mouse PITPNM3. PITPNM3 is composed of a unique N-terminus, a middle transmembrane region, and a C-terminus.

The N-terminus of PITPNM3 contains a putative transmembrane domain that is involved in the formation of the protein's local entropy and may be involved in its stability. The middle transmembrane region contains a variable-length cytoplasmic domain that is involved in the protein's localization and stability. The C-terminus of PITPNM3 contains a unique C-type nucleotide-binding oligomerization (CTNOBO) domain that is involved in the regulation of intracellular signaling pathways.

Expression of PITPNM3

PITPNM3 is highly expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is expressed in the brain at levels of around 10% of the total cell protein and in the heart at levels of around 20%. It is also expressed in the blood vessels, where it is involved in the regulation of blood pressure and blood flow.

Function and Potential Functions as a Drug Target or Biomarker

The function of PITPNM3 is not well understood, but it is involved in the regulation of intracellular signaling pathways. This makes it a potential drug target or biomarker for various diseases.

In neurodegenerative disorders, PITPNM3 has been shown to be involved in the regulation of neurotransmitter signaling pathways, including the regulation of dopamine release. This suggests that PITPNM3 may be a useful target for neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease.

In cancer, PITPNM3 has been shown to be involved in the regulation of angiogenesis, which is the process by which tumors grow and exploit the blood supply. This makes PITPNM3 a potential target for cancer therapies that target the regulation of angiogenesis.

In cardiovascular disease, PITPNM3 has been shown to be involved in the regulation of cell signaling pathways that are involved in the regulation of contractility and cardiovascular function. This suggests that PITPNM3 may be a useful target for cardiovascular disease therapies that target these pathways.

Conclusion

PITPNM3 is a protein that is expressed in various tissues of the human body and is involved in the regulation of intracellular signaling pathways. Its function in the regulation of cellular signaling pathways makes it a potential drug target or biomarker for various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Further research is needed to fully understand the role of PITPNM3 in the human body and its potential as a therapeutic target.

Protein Name: PITPNM Family Member 3

Functions: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions

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