Regulating PI Signaling: The Role of PIRT (G644139)

Target Name: PIRT

NCBI ID: G644139

PIRT

Other Name(s): Phosphoinositide-interacting protein | phosphoinositide interacting regulator of transient receptor potential channels | phosphoinositide-interacting regulator of TRPV1 | Phosphoinositide interacting regulator of transient receptor potential channels | PIRT_HUMAN

Regulating PI Signaling: The Role of PIRT

Phosphoinositide (PI) is a crucial signaling molecule that plays a vital role in various cellular processes, including cell signaling, inflammation, and cell survival. The PI system has been extensively studied, and numerous proteins have been identified that interact with PI. One such protein is the phosphorylated and interacting protein (PIRT), which has been shown to play a critical role in various cellular processes.

PIRT: A protein that regulates PI signaling

PIRT is a protein that is highly conserved across various species, including humans. It is composed of two distinct subunits, alpha and beta, which are held together by a disulfide bond. PIRT alpha is a 26-kDa protein that contains 11 known protein domains, while PIRT beta is a 17-kDa protein that contains four known protein domains.

PIRT is a highly regulated protein that is involved in various cellular processes. One of the well-documented functions of PIRT is its role in regulating PI signaling. PI signaling is a complex process that involves the recruitment of various enzymes to the site of the PI molecule. The recruitment of these enzymes is regulated by various protein interactions, including those between PIRT and PI.

In addition to its role in regulating PI signaling, PIRT is also involved in several other cellular processes, including cell adhesion, migration, and stress resistance. For example, PIRT has been shown to play a critical role in regulating the formation of neuroblasts and in the development of cancer.

Drug targeting PIRT

PIRT is a protein that has been the focus of intense research in the field of PI signaling, and as a result, it has become an attractive drug target. Several studies have shown that inhibiting PIRT can lead to the inhibition of PI signaling, thereby resulting in various cellular processes that are disrupted.

One of the well-documented drug targets for PIRT is the inhibition of the PI-loop complex, which is a critical complex for the regulation of PI signaling. The PI-loop complex consists of the PI molecule, the protein kinase CK5, and the protein adaptor protein p110-纬. The PI-loop complex plays a critical role in regulating the recruitment of enzymes to the PI molecule, and is Therefore, inhibiting the PI-loop complex can lead to the inhibition of PI signaling.

Another drug target for PIRT is the inhibition of the protein Pyknotin, which is a protein that can interact with PIRT and recruit it to the endoplasmic reticulum. The Pyknotin-PIRT interaction has been shown to play a critical role in the regulation of PI signaling.

In conclusion, PIRT is a protein that is involved in various cellular processes and has been the focus of intense research in the field of PI signaling. The inhibition of PIRT has been shown to lead to the inhibition of PI signaling, and as a result, PIRT has become an attractive drug target. Further research is needed to fully understand the role of PIRT in PI signaling and to develop effective inhibitors of PIRT.

Protein Name: Phosphoinositide Interacting Regulator Of Transient Receptor Potential Channels

Functions: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)

The "PIRT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PIRT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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