PKIA-AS1: A Potential Drug Target and Biomarker (G101927003)

Target Name: PKIA-AS1

NCBI ID: G101927003

PKIA-AS1

Other Name(s): PKIA antisense RNA 1

PKIA-AS1: A Potential Drug Target and Biomarker

Protein kinase A (PKIA) is a ubiquitous protein that plays a crucial role in cell signaling pathways. It is involved in many cellular processes, including cell growth, differentiation, and survival. The protein has four isoforms, PKIA-AS1, PKIA-AS2, PKIA-AS3, and PKIA-AS4, which differ in their size and function. In this article, we will focus on PKIA-AS1, a protein that has potential as a drug target and biomarker.

PKIA-AS1 is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and pancreas. It is a key regulator of cell signaling pathways, including the cAMP/cGMP signaling pathway, which is involved in many cellular processes, including cell growth, differentiation, and survival. PKIA-AS1 has been shown to play a role in the regulation of cell proliferation, differentiation, and survival.

One of the challenges in studying PKIA-AS1 is its high degree of complexity. There are many different isoforms of PKIA, and each isoform has a different function. It is difficult to predict the exact function of PKIA-AS1 based on its sequence alone. However, recent studies have identified several potential functions for PKIA-AS1.

One of the functions of PKIA-AS1 is to regulate the activity of the cAMP/cGMP signaling pathway. This pathway is involved in many cellular processes, including cell growth, differentiation, and survival. PKIA-AS1 has been shown to play a role in the regulation of the cAMP/cGMP signaling pathway by interacting with several different components of this pathway, including the protein kinase A2 (PKA2), the protein phosphatidylinositol 3-kinase (PI3K), and the protein CREB-p21.

Another function of PKIA-AS1 is to regulate the expression of genes involved in cell signaling pathways. This is done by interacting with the transcription factors, such as nuclear factor KLF1 and nuclear factor E2F1, to control the levels of their target genes.

PKIA-AS1 has also been shown to play a role in the regulation of cellular stress responses. Stress can cause damage to cells, and this damage can be detected by measuring the levels of various cellular stress biomarkers, such as reactive oxygen species (ROS), hydrogenperoxide (H2O2), and oxidative stress-induced cellular damage (OSAD). PKIA-AS1 has been shown to play a role in the regulation of these stress responses by interacting with the transcription factor, nuclear factor IRF-3.

In addition to its role in cell signaling pathways, PKIA-AS1 has also been shown to play a role in the regulation of cellular processes involved in inflammation and fibrosis. This is done by interacting with the transcription factor, nuclear factor NF-kappa-B.

PKIA-AS1 has also been shown to play a role in the regulation of cellular processes involved in cell adhesion and migration. This is done by interacting with the protein, cadherin.

In conclusion, PKIA-AS1 is a complex protein that plays a crucial role in cell signaling pathways. Its functions as a drug target and biomarker make it an attractive target for future research. Further studies are needed to fully understand the role of PKIA-AS1 in cellular processes and to develop effective treatments based on its properties.

Protein Name: PKIA Antisense RNA 1

The "PKIA-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PKIA-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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