INO80: A Promising Drug Target / Biomarker (G54617)

Target Name: INO80

NCBI ID: G54617

INO80

INO80: A Promising Drug Target / Biomarker

INO80 is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is a member of the superfamily of nucleotide-binding proteins (NBP), which includes proteins that are involved in various cellular processes, including DNA replication, gene expression, and signaling. INO80 has been shown to play a role in a variety of biological processes, including cell signaling, DNA replication, and metabolism. As a result, INO80 has potential as a drug target or biomarker.

The Importance of INO80

INO80 is a key regulator of DNA replication, which is a critical process for the development and maintenance of most organisms. During DNA replication, INO80 helps to ensure that the genetic information in the double helix is accurately copied into two new copies. INO80 plays a role in the regulation of DNA replication by interacting with the enzyme responsible for copying DNA, called DNA polymerase.

INO80 is also involved in the regulation of cell signaling, which is the process by which cells communicate with one another to coordinate their activities. INO80 has been shown to play a role in the regulation of several signaling pathways, including the DNA replication-protein kinase (DNAPK) pathway and the PI3K/Akt signaling pathway.

Additionally, INO80 is involved in the regulation of metabolism, which is the process by which cells convert energy and nutrients into the components necessary for growth and maintenance. INO80 has been shown to play a role in the regulation of cellular metabolism by interacting with the enzyme responsible for glucose metabolism, called GLUT1.

Potential Therapeutic Applications

The potential therapeutic applications of INO80 are vast and varied. INO80 has been shown to play a role in the development and progression of a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. As a result, INO80 has potential as a drug target or biomarker for the treatment of these diseases.

One potential therapeutic application of INO80 is the treatment of cancer. INO80 has been shown to play a role in the regulation of cell signaling, which is a critical process for the development and progression of many types of cancer. As a result, INO80 has potential as a therapeutic agent for the treatment of cancer by targeting the regulation of cell signaling.

Another potential therapeutic application of INO80 is the treatment of neurodegenerative diseases. INO80 has been shown to play a role in the regulation of cellular metabolism and has been implicated in the development and progression of neurodegenerative diseases. As a result, INO80 has potential as a therapeutic agent for the treatment of neurodegenerative diseases by targeting the regulation of cellular metabolism.

Finally, INO80 has potential as a biomarker for the diagnosis and monitoring of cardiovascular diseases. INO80 has been shown to play a role in the regulation of cell signaling and has been implicated in the development and progression of cardiovascular diseases. As a result, INO80 has potential as a biomarker for the diagnosis and monitoring of cardiovascular diseases by targeting the regulation of cell signaling.

Conclusion

INO80 is a protein that is expressed in various tissues of the body and plays a critical role in a variety of biological processes, including cell signaling, DNA replication, and metabolism. As a result, INO80 has potential as a drug target or biomarker for the treatment of a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Further research is needed to fully understand the role of INO80 in these processes and to develop effective therapies based on INO80.

Protein Name: INO80 Complex ATPase Subunit

Functions: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820)

The "INO80 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INO80 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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