Implications of PPI2R1A in Neurological and Cardiovascular Diseases

Target Name: PPP2R1A

NCBI ID: G5518

PPP2R1A

Implications of PPI2R1A in Neurological and Cardiovascular Diseases

PPI2R1A (PRO2R1A), also known as MRD36, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the PPI2R1 family, which is a subfamily of the PPI2R1 transmembrane protein family. PPI2R1A is highly expressed in the brain and has been implicated in a number of neurological and cardiovascular diseases.

Diseases associated with PPI2R1A

PPI2R1A has been implicated in a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In addition, PPI2R1A has also been linked to a number of cardiovascular diseases, including hypertension, heart failure, and stroke.

Alzheimer's disease is a progressive neurodegenerative disease that is characterized by the accumulation of neurofibrillary tangles and senile plaques in the brain. PPI2R1A has been shown to be involved in the development and progression of Alzheimer's disease, and may play a role in the regulation of neurofibrillary tangles and the production of senile plaques.

Parkinson's disease is a neurodegenerative disorder that is characterized by the loss of dopamine-producing neurons in the brain. PPI2R1A has been shown to be involved in the regulation of dopamine levels in the brain and has been implicated in the development of Parkinson's disease.

Huntington's disease is a genetic disorder that is characterized by the accumulation of huntingtin protein in the brain. PPI2R1A has been shown to be involved in the regulation of huntingtin levels in the brain and has been implicated in the development of Huntington's disease.

Cardiovascular disease is a leading cause of death in adults worldwide. PPI2R1A has been shown to be involved in the regulation of cardiovascular risk factors, including blood pressure, cholesterol, and blood sugar levels. This may have implications for the development and progression of cardiovascular disease.

Pathology and function of PPI2R1A

PPI2R1A is a transmembrane protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the PPI2R1 family, which is characterized by the presence of a transmembrane region and a cytoplasmic tail. PPI2R1A has a calculated molecular weight of 41 kDa and a calculated pI of 6.9.

PPI2R1A is involved in a number of physiological processes in the body, including cell signaling, neurotransmitter regulation, and inflammation. It is a negative regulator of the protein kinase A (PKA), which is involved in a variety of cellular processes, including cell signaling, DNA replication, and metabolism.

PPI2R1A has been shown to be involved in the regulation of neurotransmitter release from axons in the central nervous system. In addition, PPI2R1A has been shown to be involved in the regulation of pain perception and neuroinflammation.

Targeting PPI2R1A

PPI2R1A is a potential drug target and may be a useful target for the treatment of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. PPI2R1A is thought to be involved in the regulation of neurofibrillary tangles and the production of senile plaques, which are hallmarks of these diseases.

In addition, PPI2R1A may also be a useful target for the treatment of cardiovascular disease, as it is involved in the regulation of cardiovascular risk factors. PPI2R1A may be a useful target for the treatment of

Protein Name: Protein Phosphatase 2 Scaffold Subunit Aalpha

Functions: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity)

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