ACOT13: A Potential Drug Target and Biomarker (G55856)

Target Name: ACOT13

NCBI ID: G55856

ACOT13

ACOT13: A Potential Drug Target and Biomarker

Acyl-coenzyme A thioesterase 13 (ACOT13) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a key enzyme in the synthesis of the fatty acid acyl-coenzyme A (ACA), which is a central component of cell membranes and has been linked to various diseases, including cardiovascular disease and neurological disorders.

Recent studies have suggested that ACOT13 may be a drug target or biomarker for several conditions, including cardiovascular disease, neurodegenerative diseases, and autoimmune disorders. This has led to increased interest in the research of ACOT13 and its potential applications in these fields.

One of the potential reasons for the interest in ACOT13 is its role in the synthesis of ACA, which is a key component of cell membranes. ACA is involved in various cellular processes, including the transport of fatty acids and the regulation of inflammation. Several studies have shown that changes in ACA levels or its metabolism can contribute to the development of various diseases, including cardiovascular disease and neurodegenerative disorders.

Another potential reason for the interest in ACOT13 is its role in the regulation of cellular processes that are important for the health and function of brain cells. Studies have shown that ACOT13 is involved in the synthesis of various compounds that are important for the structural and functional integrity of brain cells, including the neurotransmitter dopamine. Additionally, ACOT13 has been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of synapses, which are the structural elements that allow communication between brain cells.

In addition to its role in the synthesis of ACA and other compounds, ACOT13 has also been shown to be involved in the regulation of cellular processes that are important for the health and function of various tissues and organs. For example, studies have shown that changes in ACOT13 levels or its metabolism can contribute to the development of diseases such as cancer, diabetes, and neurodegenerative disorders.

Given the potential role of ACOT13 in the regulation of cellular processes that are important for the health and function of various tissues and organs, it is an attractive target for drug development. Studies have shown that various drugs, including small molecules, peptides, and proteins, have the potential to modulate ACOT13 activity and its function.

In addition to its potential as a drug target, ACOT13 has also been shown to be a potential biomarker for several diseases. For example, studies have shown that changes in ACOT13 levels or its metabolism can be used as a diagnostic indicator for certain forms of cancer, including breast cancer. Additionally, ACOT13 has been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of neurodegenerative disorders, making it an attractive target for the development of new treatments for these conditions.

Overall, ACOT13 is a protein that has significant interest in the field of drug development and biomarker research. Its role in the synthesis of ACA and its potential involvement in the regulation of cellular processes that are important for the health and function of various tissues and organs make it an attractive target for further study. As research continues to advance, it is likely that new insights into the biology and functions of ACOT13 will emerge, further increasing its potential as a drug target and biomarker.

Protein Name: Acyl-CoA Thioesterase 13

Functions: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity)

The "ACOT13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACOT13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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