PRKX: A Protein Kinase for Cell Signaling and Disease (G5613)

Target Name: PRKX

NCBI ID: G5613

PRKX

PRKX: A Protein Kinase for Cell Signaling and Disease

PRKX, also known as protein kinase X-linked, is a protein that plays a crucial role in various cellular processes. It is a non-catalytic protein that is highly expressed in many tissues, including muscle, heart, and brain. PRKX is a key regulator of the myelin growth and maintenance, and its abnormal expression has been linked to various neurological and muscle disorders.

PRKX is a member of the protein kinase family, which includes several different isoforms that play distinct roles in cellular signaling. The most well-studied isoform is kinase A (KA), which is a potent enzyme that catalyzes theATP-catalyzed transfer of a phosphate PRKX is a distantly related member of the kinase A family, and its coding gene is located on the X chromosome.

PRKX plays an important role in cell signaling. It can activate and inhibit multiple signaling pathways, including cell cycle, proliferation, differentiation, and apoptosis. Activation of PRKX can lead to a variety of intracellular processes, such as increasing cell cycle progression, increasing cell proliferation, promoting apoptosis, etc.

Abnormal expression of PRKX has been shown to be associated with a variety of neurological and muscle diseases. For example, variations in the PRKX gene are associated with apoptosis and synaptic plasticity in rat neurons. Knockdown of the PRKX gene can also lead to the loss of contractile function of muscle cells, thereby causing muscle atrophy.

In addition, PRKX is also associated with tumor development and progression. Studies have shown that PRKX gene expression levels are related to the invasion and metastasis capabilities of various tumors. The activation of PRKX may also be related to the apoptosis and proliferation of tumor cells.

Therefore, PRKX is a very promising drug target or biomarker. By inhibiting the activity of PRKX, a variety of neurological and muscle diseases can be treated, including neurodegenerative diseases, muscle atrophy, and tumors. In addition, since PRKX is a gene on the X chromosome, it may also be a good sex-specific drug target.

Overall, PRKX is a very important protein that plays an important role in cell signaling and cell differentiation. Studying the relationship between PRKX activation and abnormal expression and neurological and muscle diseases can provide us with better treatment options. As research progresses, we may discover the potential of PRKX as a drug target or biomarker.

Protein Name: Protein Kinase CAMP-dependent X-linked Catalytic Subunit

Functions: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation

The "PRKX Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRKX comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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