PARD3: Potential Drug Target and Biomarker for Protein Phosphatase 1 (PP1) Regulatory Subunit 118

Target Name: PARD3

NCBI ID: G56288

PARD3

PARD3: Potential Drug Target and Biomarker for Protein Phosphatase 1 (PP1) Regulatory Subunit 118

Introduction

Protein phosphorylation modification has important biological functions in organisms, and it is a key step in various signal transduction pathways in organisms. Among them, phosphorylation-modifying enzymes (PPases) in protein phosphorylation modification play an important role in maintaining the stability of signal transduction pathways and degrading modified proteins. PP1 is an important PPase that plays a key role in various physiological processes. However, abnormal activation and dysregulation of PP1 play an important role in various diseases, such as cancer, neurodegenerative diseases, etc. Therefore, it is of important biological significance to study the functions and regulatory mechanisms of PP1 and its related proteins.

PARD3: 鈥嬧?婣 protein to watch

PARD3 is a eukaryotic protein, and its encoding gene is NM_006013.1. PARD3 has multiple functions in vivo, including participating in DNA damage repair, cell cycle regulation, apoptosis and other processes. In addition, PARD3 is also closely related to the occurrence and development of various diseases. For example, activation and dysregulation of PP1 play an important role in neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, etc.). In addition, PARD3 is also closely related to cancer progression and treatment response. Therefore, it is of great significance to study the role and mechanism of PARD3 in diseases.

Mechanism of action of PARD3

The mechanism by which PARD3 functions in vivo mainly includes the following aspects:

1. DNA damage repair

PARD3 is an important DNA damage repair enzyme. When cells suffer DNA damage, PARD3 can modify DNA through phosphorylation to promote the DNA repair process.

2. Cell cycle regulation

PARD3 plays an important role in cell cycle regulation. In the G1 phase, PARD3 can prevent microtubule polymerization through phosphorylation modification, thereby inhibiting spindle formation and thereby delaying cell cycle progression. In S phase, PARD3 can promote microtubule polymerization through phosphorylation modification, thereby participating in the DNA replication process.

3. Apoptosis

PARD3 plays an important role in apoptosis. Studies have found that PARD3 can regulate the apoptosis signaling pathway through phosphorylation modification, thereby participating in the process of apoptosis.

4. Participate in tumor occurrence and development

PARD3 plays an important role in tumor occurrence and development. Studies have found that PARD3 can inhibit apoptosis through phosphorylation modification, thereby promoting the growth and proliferation of tumor cells. In addition, PARD3 can also regulate the cell cycle through phosphorylation modification, thereby providing more time for tumor cell proliferation.

Biological functions of PARD3

PARD3 has a variety of biological functions in organisms, including participating in DNA damage repair, cell cycle regulation, apoptosis and other processes. These functions make PARD3 a potential drug target.

1. Disease treatment targets

PARD3 plays an important role in a variety of diseases and is therefore considered a potential drug target. For example, PARD3 plays an important role in neurological diseases such as Alzheimer's disease and Parkinson's disease. In addition, PARD3 also plays an important role in tumor cells and is therefore considered a potential tumor treatment target.

2. Disease diagnosis and prognosis biomarkers

PARD3 plays an important role in a variety of diseases in vivo and therefore can be used as a biomarker for disease diagnosis and prognosis. For example, by detecting the activity status of PARD3, the survival period of tumor patients can be predicted. In addition, PARD3 can also be used as a biomarker for neurological diseases such as Parkinson's disease, providing a basis for disease diagnosis and treatment.

3. Drug research and development

PARD3 has attracted widespread attention as a potential drug target. At present, a variety of drugs that inhibit PARD3 activity have been successful in preclinical research, including inhibitors, site inhibitors, etc. These drugs are expected to become effective treatments for various diseases in the future.

Conclusion

As an important protein, PARD3 has a variety of biological functions in organisms, including participating in DNA damage repair, cell cycle regulation, apoptosis and other processes. PARD3 plays an important role in a variety of diseases and is therefore considered a potential drug target. In addition, PARD3 is also a potential biomarker for disease diagnosis and prognosis. With the deepening of research, PARD3 is expected to provide new means and ideas for the treatment of various diseases.

Protein Name: Par-3 Family Cell Polarity Regulator

Functions: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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