PARP10: A Promising Drug Target for Various Diseases (G84875)

Target Name: PARP10

NCBI ID: G84875

PARP10

PARP10: A Promising Drug Target for Various Diseases

PARP10 (PARP-10) is a protein that is expressed in various tissues throughout the body, including the brain, spinal cord, and peripheral nerves. It is a key regulator of the DNA damage response, which is a critical process that helps the body repair damage to its DNA.

Recent studies have identified PARP10 as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because the DNA damage response is often disrupted in these conditions, and PARP10 has been shown to play a role in repairing this damage.

One of the reasons why PARP10 is a promising drug target is that it is highly conserved across different species. This means that studies on one species can be applied to other species, which can help researchers identify potential drug targets that are relevant to a wide range of organisms.

In addition, PARP10 is involved in a number of important cellular processes that are relevant to many diseases. For example, it is involved in the repair of DNA damage caused by environmental toxins, such as radiation and chemical drugs. It also plays a role in the regulation of cell death, which is important in the development of many diseases, including cancer.

Furthermore, PARP10 is a good candidate for a drug because it is highly druggable. This is because its structure allows researchers to design small molecules that can interact with specific residues on the protein, which can lead to a blocking of the protein's activity. similar to the way that many drugs work, by blocking the activity of a specific protein or enzyme.

In conclusion, PARP10 is a protein that is expressed in various tissues throughout the body and is involved in the DNA damage response. As a result, it is a promising drug target for a variety of diseases. Further research is needed to fully understand the role of PARP10 in the development and progression of these diseases, and to identify effective small molecules that can be used to treat these conditions.

Protein Name: Poly(ADP-ribose) Polymerase Family Member 10

Functions: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737)

The "PARP10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PARP10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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